急性淋巴细胞白血病患儿严重神经系统不良反应1例的药学监护  

Pharmaceutical Care of Severe Neurotoxicity in a Child with Acute Lymphoblastic Leukemia

作　　者：曾缘缘 杨巨飞[2] 许静[1] Zeng Yuanyuan;Yang Jufei;Xu Jing(Children's Hospital of Nanjing Medical University,Jiangsu Nanjing 210008,China;Children's Hospital of Zhejiang University School of Medicine,Zhefiang Hangzhou 310003,China)

机构地区：[1]南京医科大学附属儿童医院,江苏南京210008 [2]浙江大学医学院附属儿童医院,浙江杭州310003

出　　处：《儿科药学杂志》2018年第12期35-38,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨泊沙康唑和长春地辛联用诱发急性淋巴白血病患儿神经毒性的原因及干预措施,提高临床药师的药学监护能力。方法:对1例急性淋巴细胞白血病患儿联合使用泊沙康唑和长春地辛诱发严重神经毒性的病例进行分析与讨论,并复习相关文献。结果:患儿联合使用泊沙康唑和长春地辛后出现了严重的神经毒性反应,予以暂缓化疗后患儿状态逐渐好转。结论:临床药师需要加强对三唑类抗真菌药物和长春碱类化疗药物合用时出现严重神经系统毒性的关注,如果出现需要及时评估,协同医生共同完成患儿的治疗。Objective:To explore the causes and intervention measures of neurotoxicity in children with acute lymphoblastic leukemia induced by combination of posaconazole and vindesine,and to improve the understanding and ability of pharmaceutical care of clinical pharmacists.Methods:Data of acute neurotoxicity induced by posaconazole and vindesine in a child with acute lymphoblastic leukemia was analyzed and discussed,and related literature review was conducted.Results:After the combination of posaconazole and vindesine, the child was going through the neurotoxicity,and the condition gradually improved after the chemotherapy was temporarily stopped. Conclusion:Clinical pharmacists should pay more attention to the serious neurotoxicity in the combination of triazole antifungal drugs and vincristine chemotherapy drugs,and cooperate with the clinicians to complete the treatment if timely evaluation is needed.

关 键 词：泊沙康唑 长春地辛 药物相互作用 神经毒性 药学监护 

分 类 号：R969.3[医药卫生—药理学]