白癜风患者血清硫酸脱氢表雄酮水平与白细胞介素-6水平的关系  

Study on the relationship between serum level of dehydroepiandrosterone sulfate and interleukin-6 level in patients with vitiligo

作　　者：黄珍 范飞翔 张肄鹏 HUANG Zhen;FAN Fei-xiang;ZHANG Yi-peng(Department of Dermatology,Shenzhen Longhua District Central Hospital,Shenzhen 518110,Guangdong,CHINA)

机构地区：[1]深圳市龙华区中心医院皮肤科,广东深圳518110

出　　处：《海南医学》2018年第22期3193-3195,共3页Hainan Medical Journal

基　　金：广东省深圳市龙华区2018科技创新专项资金项目(编号:2017047)

摘　　要：目的检测白癜风患者血清硫酸脱氢表雄酮(DHEA-S)水平,并探讨其与白细胞介素-6 (IL-6)水平的关系,进而为白癜风的诊治提供新的思路。方法选择2017年1月至2018年6月间深圳市龙华区中心医院皮肤科诊治的白癜风患者120例为研究对象,其中进展期76例,稳定期44例。选择健康体检者120例纳入对照组。采用电化学发光法和酶联免疫吸附法检测不同组别受检者血清DHEA-S和IL-6水平,并分析白癜风患者DHEA-S水平与IL-6水平的相关性。结果进展期组和稳定期组患者的血清DHEA-S水平分别为(188.32±58.82)μg/dL和(210.29±90.38)μg/dL,均明显低于对照组的(290.58±124.97)μg/dL,且进展期组低于稳定期组,差异均有统计学意义(P<0.05);进展期组和稳定期组患者的IL-6水平分别为(73.46±22.47) ng/L和(60.28±21.13) ng/L,均明显高于对照组的(38.15±14.46) ng/L,且进展期组高于稳定期组,差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,白癜风患者DHEA-S水平与IL-6水平呈显著负相关(r=-0.428,P<0.05)。结论白癜风患者血清DHEA-S水平降低,其与疾病活动状态及血清IL-6水平相关,提示DHEA-S和IL-6可能共同参与白癜风的发病。Objective To detect the serum level of dehydroepiandrosterone sulfate(DHEA-S) in patients with vitiligo, and explore its relationship with the serum level of interleukin-6(IL-6), and provide new ideas for the diagnosis and treatment of vitiligo. Methods From January 2017 to June 2018, 120 patients with vitiligo who were diagnosed and treated in the Department of Dermatology at Shenzhen Longhua District Central Hospital were selected as the subjects, including 76 patients in progressive stage and 44 patients in stable stage. A total of 120 healthy people were selected into the control group. The serum levels of DHEA-S and IL-6 in different groups were determined by electrochemiluminescence immunoassay and enzyme linked immunosorbent assay, and the correlation between DHEA-S level and IL-6 level in vitiligo patients was analyzed. Results The serum DHEA-S levels in the progressive group and the stable group were(188.32±58.82) μg/dL and(210.29±90.38) μg/dL, respectively, both of which were significantly lower than(290.58±124.97) μg/dL in the control group; and the DHEA-S level in the progressive group was significantly lower than that in the stable group; all differences were statistically significant(P<0.05). The serum IL-6 levels in the progressive group and the stable group were(73.46±22.47) ng/L and(60.28±21.13) ng/L, respectively, both of which were significantly higher than(38.15±14.46) ng/L in the control group; and the IL-6 level in the progressive group was significantly higher than that in the stable group; all differences were statistically significant(P<0.05). In patients with vitiligo, Pearson correlation analysis showed that the serum level of DHEA-S was significantly negatively correlated with the levels of IL-6(r=-0.428, P<0.05). Conclusion The serum DHEA-S level is significantly decreased in vitiligo patients,which is related to disease activity and serum IL-6 level, suggesting that DHEA-S and IL-6 may be involved in the pathogenesis of vitiligo.

关 键 词：白癜风 硫酸脱氢表雄酮 白细胞介素-6 相关性 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]