头孢唑肟钠对急性细菌性感染者的细菌学疗效与血清白细胞介素6及超敏C-反应蛋白影响  

Effect of ceftizoxime sodium on bacteriological and serum interleukin-6 and hypersensitive C-reactive protein in patients with acute bacterial infection

作　　者：朱杨 颜佩文 Zhu Yang;Yah Peiwen(Department of Pharmacy,Taikang Xianlin Drum Tower Hospital,Nanjing 210000,China)

机构地区：[1]泰康仙林鼓楼医院药剂科,南京市210000

出　　处：《中华实验和临床感染病杂志（电子版）》2018年第5期494-498,共5页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的研究头孢唑肟钠对急性细菌性感染者的细菌学疗效以及对血清白细胞介素6(IL-6)和超敏C-反应蛋白(hs-CRP)水平的影响。方法选取2017年1月至2017年8月于泰康仙林鼓楼医院接受治疗的急性细菌性感染者180例,按照随机数字表法分为对照组(90例)和观察组(90例)。对照组患者静脉注射头孢曲松钠,2.0 g/次、2次/d;观察组患者静脉注射头孢唑肟钠,2.0 g/次、2次/d。比较两组患者的细菌学疗效以及治疗前后血清IL-6和hs-CRP水平。结果对照组和观察组患者有效率分别为92.22%和93.33%,差异无统计学意义(χ~2=1.267、P=0.058)。两组患者细菌培养阳性率和细菌清除率差异均无统计学意义(χ~2=1.274、P=0.062,χ~2=2.266、P=0.067)。对照组和观察组患者治疗后血清IL-6水平均较治疗前显著降低,差异有统计学意义(t=12.471、P=0.032,t=13.892、P=0.031)。对照组和观察组患者治疗后hs-CRP水平均较治疗前显著降低,差异有统计学意义(t=11.533、P=0.023,t=14.791,P=0.019)。结论头孢唑肟钠对急性细菌性感染者疗效较好,与头孢曲松钠疗效相当,能显著降低患者血清IL-6和hs-CRP水平。Objective To investigate the bacteriological effect of cefazoxime sodium on acute bacterial infection and the effect of cefazoxime sodium on serum interleukin 6(IL-6)and hypersensitive C reactive protein (hs-CRP)levels.Methods From January 2017 to August 2017,a total of 180 patients with acute bacterial infections were selected and divided into control group (90 cases)and observation group (90cases)by the random digital table method.Ceftriaxone sodium was injected intravenously in control group (once 2.0 g,2times per day),while in observation group,cefazoxime sodium (once 2.0 g,2 times per d)was injected intravenously.The bacteriological efficacy and serum IL-6and hs-CRP levels before and after treatment were compared between the two groups.Results The effective rates of control group and observation group were 92.22%and 93.33%, respectively (X^2=1.267,P =0.058).There was no significant difference in positive rate of bacterial culture and bacterial clearance rate between the two groups (X^2=1.274,P =0.062;X^2=2.266,P =0.067).The levels of serum IL-6 in control group and observation group were significantly lower than those before treatment,with statistically significant difference (t =12.471,P =0.032;t =13.892,P =0.031).The levels ofhs-CRP in the control group and observation group were significantly lower than those before treatment (t =11.533,P =0.023;t =14.791,P =0.019). Conclusions Cefazoxime sodium is effective in treatment of acute bacterial infection,which is similar to that of cefhiaxone sodium,and could significantly reduce the levels of serum IL-6 and hs-CRP.

关 键 词：头孢唑肟钠 细菌学疗效:白细胞介素6 超敏C-反应蛋白 

分 类 号：R515[医药卫生—内科学]