聚酯酰胺的合成  

Synthesis of Poly(Ester Amide)

作　　者：高晗 徐军[2] 胡欣 朱宁 郭凯 Han Gao;Jun Xu;Xin Hu;Ning Zhu;Kai Guo(College of Biotechnology and Pharmaceutical Engineering,State Key Laboratory of Material Chemistry Engineering,Nanjing Tech University,Nanjing 211800,China;College of Materials Science and Engineering,Nanjing Tech University,Nanjing 211800,China;Caprolactam Division,SINOPEC Baling Company,Yueyang 414000,China)

机构地区：[1]南京工业大学生物与制药工程学院材料化学工程国家重点实验室,南京211800 [2]中国石油化工股份有限公司巴陵分公司己内酰胺事业部,岳阳414000 [3]南京工业大学材料科学与工程学院,南京211800

出　　处：《化学进展》2018年第11期1634-1645,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21878145;21504039;21522604;U1463201);江苏省先进生物制造创新中心(No.XTD1823;XTD1821;XTB1802)资助~~

摘　　要：聚(酯酰胺)(PEA)的主链中同时具有酯键和酰胺键,兼具了聚酯(polyester)的生物降解性和相容性以及聚酰胺(polyamide)优异的机械性能,在药物控释、组织工程以及热塑性弹性体等领域应用广泛。缩合聚合是合成聚酯酰胺最初的方法,近年来开环聚合(ROP)成为制备聚酯酰胺的主要策略,本文从环状单体均聚、环状单体共聚、环状单体和线形单体共聚等方面总结了聚酯酰胺合成的研究进展。同时,介绍了基于多组分聚合反应(MCP)的新合成方法,并对聚酯酰胺材料的发展进行了探讨和展望。Poly (ester amide)(PEA)is a class of functional polymers with both amide and ester linkages in the polymer main chains.Due to the outstanding biodegradability,biocompatibility and mechanical property,PEA has broad applications in drug delivery,tissue engineering and thermoplastic elastomer.Polycondensation is the original synthetic method to PEA.Recently,remarkable achievements have been made in synthesis of PEA via ring-opening polymerization(ROP).This review summarizes the progress in ROP of cyclic monomers,ringopening copolymerization (ROCP)of cyclic monomers and ROCP of cyclic/linear momomers.Moreover, multicomponent polymerization (MCP)is highlighted as a novel synthetic strategy to prepare PEA.The challenge and outlook of PEA are also discussed.

关 键 词：聚酯酰胺 开环聚合 多组分聚合 

分 类 号：O632.6[理学—高分子化学] O633.14[理学—化学]