不同剂量和煎煮时间对附子镇痛抗炎作用的影响  

Analgesic and Anti-inflammatory Effects of Different Dose and Boil time of Aconiti lateralis radix praeparata

作　　者：段小花[1] 马晓霞[1] 李兆福[2] 李玲玉[2] 普勇斌[2] 彭江云[2] DUAN Xiao-hua;MA Xiao-xia;LI Zhao-fu;LI Ling-yu;PU Yong-bin;PENG Jiang-yun(Yunnan Key Laboratory of Dai and Yi Medicines,Yunnan University of Traditional Chinese Medicine,Kun-ming 650500,China;Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南中医学院云南省傣医药与彝医药重点实验室(筹备),云南昆明650500 [2]云南省中医医院,云南昆明650021

出　　处：《时珍国医国药》2018年第10期2385-2387,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家中医药管理局中医学术流派传承工作室建设项目(LP0125056);云南省重点实验室培育计划(2017DG006)

摘　　要：目的比较不同剂量和煎煮时间附子的镇痛抗炎作用差异。方法通过醋酸扭体法,以小鼠扭体反应次数为考察指标,观察不同剂量和煎煮时间附子的镇痛作用;通过二甲苯致小鼠耳肿胀法,以小鼠耳肿胀度为考察指标,观察不同剂量和煎煮时间附子的抗炎作用。结果与模型组比较,附片30g煎0. 5h、1. 5h、2. 0h、2. 5h组,附片60g煎0. 5h、1. 5h、2. 0h、2. 5、3. 0h组及附片100g煎3. 0h组均可明显抑制冰醋酸所致小鼠的扭体反应次数(P <0. 05);附片30g煎0. 5h、1. 5h、2. 0h、2. 5h、3. 0h组及附片60g煎1. 5h、2. 0h、2. 5h、3. 0h组均可明显降低二甲苯所致小鼠耳肿胀度(P <0. 05)。结论不同剂量和煎煮时间对附子的镇痛抗炎作用不尽相同,30g和60g煎煮的镇痛抗炎作用明显。Objective To campare analgesic and anti-inflammatory effects of different dose and boil time of Aconiti lateralis radix praparata. Methods The analgesic effect of different dose and boil time of Aconiti lateral-radix praparata was tested by the acetic acid-induced writhing body method in mice. The anti-inflammatory effect of different dose and boil time of Aconiti lateralis radix praparata was tested by the xylene-induced ear swelling method in mice. Results Aconiti lateralis radix praparata 30 g boil 0. 5 h,1. 5 h,2. 0 h,2. 5 h,60 g boil 0. 5 h,1. 5 h,2. 0 h,2. 5,3. 0 h,100 g boil 3. 0 h obviously decreased the times of the acetic acid-induced writhing test in mice(P < 0. 05); Aconiti lateralis radix praparata 30 g boil 0. 5 h,1. 5 h,2. 0 h,2. 5 h,3. 0 h,60 g boil1. 5 h,2. 0 h,2. 5 h,3. 0 h obviously inhibited the xylene-induced ear swelling(P < 0. 05). Conclusion There are different degrees of analgesic and anti-inflammatory effects in different dose and boil time of Aconiti lateral-radix praparata. The 30 g and 60 g have obviously analgesic and anti-inflammatory effects.

关 键 词：附子 剂量 煎煮时间 镇痛 抗炎 

分 类 号：R283.1[医药卫生—中药学]