钯催化下膦盐与烯丙基胺的偶联反应  

Pd-catalyzed Coupling Reaction of Phosphonium Salts With Allylic Amines

作　　者：于静 韩翠杰 江梦园 马献涛 YU Jing;HAN Cui-jie;JIANG Meng-yuan;MA Xian-tao(College of Chemistry and Chemical Engineering,Xinyang Normal University,Henan Xinyang 464000,China)

机构地区：[1]信阳师范学院化学化工学院,河南信阳464000

出　　处：《辽宁化工》2018年第11期1077-1080,共4页Liaoning Chemical Industry

基　　金：河南省高等学校重点科研项目计划;项目号:19B150018;信阳师范学院南湖学者奖励计划青年项目;信阳师范学院青年骨干教师资助计划;项目号:2018GGJS-05资助

摘　　要：报道了无酸性添加剂条件下,5 mol%Pd(PPh3)4催化的膦盐与烯丙基胺的直接偶联反应,以32%～74%收率高效地合成α,β-不饱和酮、酯和腈。对照试验表明:烯丙基胺在该反应中展现出其他烯丙化试剂无可替代的优势。5% (mol) Pd(PPh3)4-catalyzed additive-free cross coupling of phosphonium salts with allylic amines was carried out for the efficient synthesis of a,p-unsaturated ketones, esters and nitriles (32%~74% yields). Control experiments showed that allylic amines were far superior to other allylic reagents.

关 键 词：膦盐 烯丙基胺 烯丙化-Wittig反应 Α Β-不饱和酮 酯和腈 

分 类 号：O621.3[理学—有机化学]