T波峰-T波末间期与左室舒张功能关系的研究  

Study on the association between Tp-Te interval and left ventricular diastolic function

作　　者：李蕾[1] 李凯 LI Lei;LI Kai(Department of Emergency,Zhangjiagang Hospital Affiliated to Soochow University,the First People's Hospital of Zhangjiagang,Jiangsu Zhangjiagang 215600,China)

机构地区：[1]苏州大学附属张家港医院,张家港市第一人民医院急诊科,江苏张家港215600

出　　处：《中国医刊》2018年第12期1336-1339,共4页Chinese Journal of Medicine

摘　　要：目的研究T波峰-T波末(Tp-Te)间期与左室舒张功能的关系,评价Tp-Te间期与左室舒张功能不全的相关性。方法选取张家港市第一人民医院2015年6月至2017年5月符合左室舒张功能不全及舒张性心力衰竭诊断标准的176例患者作为观察组,另选择同期来院体检的健康人群201例作为对照组,收集所有研究对象的超声心动图相关指标,包括左房内径(left artial diameter,LAD)、左室舒张末期内径(left ventricular end-diastolic diameter,LVEDd)、左室后壁厚度(left ventricular posterior wall,LVPW)、室间隔厚度(interventricular septal thickness,IVST),以及血清B型钠尿肽前体(pro B type natriuretic peptide,pro-BNP)水平,并测量其12导同步心电图的V2导联Tp-Te间期、校正的Tp-Te(Tp-Tec)间期以及QT间期与校正的QT(QTc)间期。比较两组的Tp-Te、Tp-Tec、QT、QTc间期长度及LAD、LVPW、IVST、pro-BNP变化,运用Pearson分析Tp-Te、Tp-Tec与各参数的相关性。结果观察组Tp-Te与Tp-Tec间期长度均较对照组显著延长(P<0.05),且LAD、LVPW、IVST、pro-BNP均显著高于对照组(P<0.05)。Pearson相关分析显示,Tp-Te、Tp-Tec间期长度与LAD、LVPW、IVST、pro-BNP呈正相关(P<0.05)。结论左室舒张功能不全患者Tp-Te与Tp-Tec间期明显延长,LAD、LVPW、IVST显著增加,Tp-Te和Tp-Tec间期长度可反映左室舒张功能不全的严重程度。Objective To study the Tp-Te interval and its relationship with left ventricular diastolic function, evaluation of the correlationwith Tp-Te interval and left ventricular diastolic dysfunction. Method Retrospective selected patients who were diagnosed as leftventricular diastolic dysfunction and diastolic heart failure as observation group,and selected normal people as control group.Collectedechocardiography related indicators as left artial diameter (LAD), left ventricular end-diastolic diameter (LVEDd), left ventricular posteriorwall (LVPW), interventricular septal thickness (IVST) and pro B type natriuretic peptide (pro-BNP) of all subjects,and measured all ofthem Tp-Te interval,corrected Tp-Te (Tp-Tec) interval and QT interval and corrected QT (QTc) interval in lead V2 of 12 lead synchronouselectrocardiogram.Compared the length of Tp-Te, Tp-Tec, QT, QTc and the changes of LAD, LVPW, IVST, pro-BNP between the twogroups. Result The Tp-Te and Tp-Tec in the observation group were significantly longer than control group (P<0.05); the levels of LAD,LVPW, IVST, pro-BNP in the observation group were higher than control group (P<0.05); Tp-Te and Tp-Tec were positively correlatedwith LAD, LVPW, IVST, pro-BNP (P<0.05). Conclusion Tp-Te and Tp-Tec were both significantly prolonged in patients with leftventricular diastolic dysfunction. LAD, LVPW, IVST were increased significantly in patients with left ventricular diastolic dysfunction,suggesting which existing ventricular remodeling and the changes of Tp-Te and Tp-Tec were related to ventricular remodeling. Tp-Te andTp-Tec can reflect the severity of left ventricular diastolic dysfunction.

关 键 词：T波峰-T波末间期 左室舒张功能不全 舒张性心力衰竭 

分 类 号：R816.2[医药卫生—放射医学]