血清TGF-β1和CTGF水平对长程持续性房颤术后复发的预测价值  

The values of the serum levels of TGF-β1 and CTGF for predicting rhythm outcomes in patients with long-standing atrial fibrillation undergoing catheter ablation

作　　者：张道良[1] 邹广琛 周立[1] 姜伟峰[1] 王远龙[1] 吴绍辉[1] 徐楷[1] 刘旭[1] ZHANG Dao-liang;ZOU Guang-chen;ZHOU Li;JIANG Wei-feng;WANG Yuan-long;WU Shao-hui;XU Kai;LIU Xu(Department of Cardiology,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China)

机构地区：[1]上海市胸科医院上海交通大学附属胸科医院心内科,上海市200030

出　　处：《中国分子心脏病学杂志》2018年第5期2606-2608,共3页Molecular Cardiology of China

基　　金：上海市卫生和计划生育委员会中医药科研课题(2018JP009)

摘　　要：目的探讨长程持续性房颤患者血清TGF-β1和CTGF的水平对长程持续性房颤术后复发的预测价值。方法入选92例行房颤射频消融术的长程持续性房颤患者,根据入选患者的年龄、性别比例采集健康人群血清作为对照组(n=30)。采用ELISA法分别检测入选患者和对照组血清TGF-β1和CTGF水平。结果根据随访结果将患者分为房颤未复发组(n=48)与房颤复发组(n=44)。与正常对照组相比,房颤未复发组与房颤复发组血清TGF-β1与CTGF水平均显著升高;房颤复发组血清TGF-β1水平较房颤未复发组明显增加;房颤复发组中血清TGF-β1与CTGF水平呈负相关;Logistic回归分析发现血清TGF-β1水平与房颤持续时间是长程持续性房颤术后复发的独立危险因素。结论长程持续性房颤患者血清TGF-β1与CTGF水平明显升高;房颤复发组血清TGF-β1水平升高更显著,且其与CTGF水平呈负相关;血清TGF-β1水平和房颤持续时间对长程持续性房颤术后复发有预测价值。Objective To investigate the serum levels of TGF-β1 and CTGF in patients with long-standing atrial fibrillation(AF)undergoing catheter ablation and their values for predicting rhythm outcomes. Methods 92 patients with long-standing AF undergoing catheter ablation were enrolled. Meanwhile 30 age-and gender-matched healthy individuals from the population were chosen as controls. Serum levels of TGF-β1 and CTGF were measured using commercial ELISA assays. Results During follow-up, 44 patients in the AF group experienced AF recurrence(AF recurrence group) and 48 patients were free from atrial tachyarrhythmias(non-AF recurrence group).Compared with controls,the serum levels of TGF-βl and CTGF were significantly elevated in both the AF recurrence group and non-AF recurrence group. Serum levels of TGF-β1 were significantly higher in the AF recurrence group than that in the non-AF recurrence group. A significant negative correlation was found between the serum levels of CTGF and TGF-β1 in the AF recurrence group. In the Logistic regression analysis, longer AF duration and increased serum levels of TGF-β1 were found to be independent risk factors for AF recurrence. Conclusion The serum levels of TGF-β1 and CTGF are significantly elevated in patients with long-standing persistent AF undergoing catheter ablation compared with healthy controls. In patients with long-standing AF undergoing catheter ablation, the serum levels of TGF-β1 are higher in those who will suffer from recurrences, and in those patients the serum TGF-β1 levels are negatively correlated with CTGF levels. Longer AF duration and higher serum levels of TGF-β1 in procedure are independent risk factors for AF recurrences after catheter ablation.

关 键 词：TGF-β1 CTGF 心房纤维化 心房颤动 导管消融 

分 类 号：R541.75[医药卫生—心血管疾病]