TAM受体信号通路在自身免疫疾病中的研究进展  

The research progress of TAM signaling pathway in autoimmune diseases

作　　者：赵宇[1,2] 关海霞 Zhao Yu;Guan Haixia(Department of Endocrinology and Metabolism,Institute of Endocrinology,Liaoning Provincial Key Laboratory of Endocrine Diseases,the First Affiliated Hospital of China Medical University,Shenyang 110001,China;Changsha Ninger Obstetrics and Gynecology Hospital,Changsha 410006,China)

机构地区：[1]中国医科大学第一附属医院内分泌代谢科、内分泌研究所、辽宁省内分泌疾病重点实验室,沈阳110001 [2]长沙宁儿妇产医院,410006

出　　处：《国际免疫学杂志》2018年第5期546-549,共4页International Journal of Immunology

基　　金：国家自然科学基金(81570708)。

摘　　要：TAM受体是新近发现的一个受体酪氨酸激酶亚家族,包括Tyr03,Mer和Axl,在免疫系统的调控及凋亡细胞的吞噬上发挥着重要作用。TAM受体在单核细胞、巨噬细胞及其它免疫细胞上均有表达。近期大量研究显示其在许多自身免疫性疾病患者中表达异常,如系统性红斑狼疮、炎症性肠病以及类风湿性关节炎等,因此研究TAM受体信号通路的一般生物学特性及其与自身免疫疾病的关系具有重要意义。TAM receptors are new sub-family of tyrosine kinase receptors family,which include Tyro3, Mer and Axl.They play an important part in the regulation of immune system and phagocytosis of apoptotic cells.TAM receptors are expressed in monocytes,macrophage and other immune cells.Recent studies have shown that TAM aberranfly expressed in patients with autoimmune diseases,such as systemic lupus erythematosus,inflammatory bowel disease,rheumatoid arthritis.It is might be important to determine the biological charac- teristics of TAM and their correlation with autoimmune diseases.

关 键 词：TAM信号通路 自身免疫疾病 固有免疫 

分 类 号：R593.2[医药卫生—内科学]