寨卡病毒感染与器官损伤  

Zika virus infection and organ injury

作　　者：唐秋菊 庞伟[2] 郑昌博 Tang Qiuju;Pang Wei;Zheng Changbo(School of Pharmaceutical Science &Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University ,Kunming650500,China;Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China)

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,650500 [2]中国科学院昆明动物研究所、中国科学院和云南省动物模型与人类疾病机理重点实验室,昆明650223

出　　处：《国际免疫学杂志》2018年第5期559-564,共6页International Journal of Immunology

基　　金：国家重点研发计划课题(2016YFC1201000);云南省活性多肽研究与利用重点实验室开放课题(AMHD-2017-3)。

摘　　要：随着近年来寨卡病毒(zikavirus,ZIKA)疫情多地区频繁爆发,ZIKA病毒感染危害逐渐引起全球高度关注。虽然ZIKA病毒的主要危害是孕妇感染所伴随的新生儿头小畸形,但越来越多的证据表明,ZIKA还能引起患者其他系统器官的损伤和危害。现就ZIKA病毒感染患者神经系统、生殖系统、胎儿以及胎盘等器官损伤研究及其机制的新进展进行综述。Zika virus ( ZIKA) broken out more frequentiy in many areas in recent years and attracted global attention. Although the main hazard of the ZIKA virus is the neonatal microcephaly associated with maternal infection,there is increasing evidence showed that ZIKA can also damage the patients, other systemic organs. This paper summarizes the research progress and the mechanisms of the damage on nervous system, reproductive system,fetus and placenta in patients with ZIKA virus infection.

关 键 词：寨卡病毒 新生儿头小畸形 格林-巴利综合征 睾丸损伤 

分 类 号：R511[医药卫生—内科学]