健脾益心方联合西药治疗冠心病稳定型心绞痛(心脾两虚)随机平行对照研究  

Jianpi Yixin Fang(健脾益心方) combined with Western Medicine in the Treatment of Coronary Heart Disease with Stable Angina Pectoris(Xinpi Liangxu/心脾两虚) Random Parallel Control Study

作　　者：蓝登科 LAN Dengke(Heshan Hospital of Traditional Chinese Medicine,Heshan 529700,Guangdong,China)

机构地区：[1]广东省鹤山市中医院内一科,广东鹤山529700

出　　处：《实用中医内科杂志》2018年第10期21-24,共4页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察健脾益心方联合西药治疗冠心病稳定型心绞痛(心脾两虚)疗效。[方法]使用随机平行对照方法,将80例门诊患者按就诊顺序号方法随机分为两组。对照组40例维拉帕米,100mg/次,3次/d;美托洛尔,100mg/次,2次/d;阿司匹林,100ng/次,3次/d;辛伐他汀,40mg/次,每晚口服;心绞痛发作时,硝酸甘油,0.5mg/次,舌下含服。治疗组40例健脾益心方(黄芪、党参、酸枣仁各30g,白术、茯苓、远志、佛手、延胡索、当归、红花、丹参各15g,甘草6g),水煎300mL,1剂/d,2次/d;西药治疗同对照组。连续治疗12周为1疗程。观测临床表现、心绞痛疗效、心电图疗效、硝酸甘油疗效、胆固醇(TC)、甘油三酯(TG)、高密度胆固醇(HDL-C)、低密度胆固醇(LDL-C)、不良反应。治疗1疗程(12周),判定疗效。[结果]心绞痛疗效:治疗组显效20例,有效11例,无效9例,总有效率77.50%;对照组显效10例,有效12例,无效18例,总有效率55.00%;治疗组疗效优于对照组(P<0.05)。心电图疗效:治疗组显效15例,有效10例,无效15例,总有效率65.50%;对照组显效7例,有效9例,无效24例,总有效率40.00%;治疗组疗效优于对照组(P<0.05)。硝酸甘油疗效:治疗组显效22例,有效10例,无效8例,总有效率80.00%;对照组显效14例,有效8例,无效18例,总有效率55.00%;治疗组疗效优于对照组(P<0.05)。TC、TG、HDL-C、LDL-C两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。[结论]健脾益心方联合西药治疗冠心病稳定型心绞痛(心脾两虚),疗效满意,无严重不良反应,值得推广。[Objective] To observe the curative effect of Jianpi Yixin Fang combined with western medicine on stable angina pectoris of coronary heart disease(Xinpi Liangxu).[Methods] Eighty outpatients were randomly divided into two groups according to the order of visiting.Control group 40 cases verapamil,100 mg/time,3 times/day;metoprolol,100 mg/time,2 times/day;aspirin,100 ng/time,3 times/day;simvastatin,40 mg/time,oral every night;angina attack,nitroglycerin,0.5 mg/time,sublingual.In the treatment group,40 cases were treated with Jianpi Yixin Fang(Huangqi,Dangshen,Suanzaoren each 30 g,Baizhu,Fuling.Yuanzhi,Foshou,Yanhusuo,Danggui,Honghua,Danshen each 15 g,Gancao 6 g),decoction 300 mL,western medicine treatment with the control group.Continuous treatment for 12 weeks was 1 courses.Clinical manifestations,angina pectoris,electrocardiogram,nitroglycerin,cholesterol(TC),triglyceride(TG),high density cholesterol(HDL-C),low density cholesterol(LDL-C),adverse reactions were observed.The course of treatment was 1 weeks(12 weeks),and the curative effect was judged.[Results] The curative effect of angina pectoris:the treatment group was markedly effective in 20 cases,effective in 11 cases,ineffective in 9 cases,the total effective rate was 77.50%;the control group was markedly effective in 10 cases,effective in 12 cases,ineffective in 18 cases,the total effective rate was 55.00%;the treatment group was better than thecontrol group(P<0.05).Electrocardiogram curative effect:the treatment group was markedly effective in 15 cases,effective in 10 cases,ineffective in 15 cases,the total effective rate was 65.50%;the control group was markedly effective in 7 cases,effective in 9 cases,ineffective in 24 cases,the total effective rate was 40.00%;the treatment group was better than the control group(P<0.05).Nitroglycerin treatment group:22 cases were markedly effective,10 cases were effective,8 cases were ineffective,the total effective rate was 80.00%;the control group was markedly effective in 14 cases,8 cases were effective,18 cases wer

关 键 词：冠心病稳定心绞痛 胸痹 真心痛 心脾两虚 健脾益心方 维拉帕米 美托洛尔 阿司匹林 辛伐他汀 硝 酸甘油 心绞痛疗效 心电图疗效 硝酸甘油疗效 胆固醇 甘油三酯 高密度胆固醇 低密度胆固醇 中药复方 随机平行对照研究’.' 

分 类 号：R541.4[医药卫生—心血管疾病]