Ski在细胞增殖、转化、胶原分泌和炎性反应中的调节作用  

The Regulatory Role of Ski in Cell Proliferation, Transformation, Collagen Secretion and Inflammatory Response

作　　者：李平[1] 周元国[1] Li Ping;Zhou Yuanguo(The Molecular Biology Center,State Key Laboratory of Trauma,Burn and Combined Injury,Research Institute of Surgery and Daping Hospital,Army Medical University,Chongqing 400042,China)

机构地区：[1]陆军军医大学大坪医院野战外科研究所分子生物学中心,创伤、烧伤和复合伤国家重点实验室,重庆400042

出　　处：《中国细胞生物学学报》2018年第11期1793-1798,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:30801195)和创伤;烧伤与复合伤国家重点实验室自主研究基金(批准号:SKLZZ200805)资助的课题~~

摘　　要：ski是病毒癌基因v-ski的细胞内同源物,其蛋白产物Ski参与了造血细胞增殖、肌肉再生、骨和神经系统发育和突触投射以及组织创伤愈合、纤维化、肿瘤发生及增殖等多种生理病理过程。Ski作为一个多功能的转录调节因子,参与了多种分子信号的调节。该文将对Ski在细胞增殖、转化、胶原分泌和炎性反应中的调节作用及机制进行综述。ski gene is known as the cellular homologue of the avian sarcoma viral oncogene (v-ski). The protein encoded by ski gene is a multifunction regulatory factor in many physiological and pathological processes, which has been reported to be involved in hematopoietic cell proliferation, muscle regeneration, the development of bone and nervous system,synaptic projection,wound healing and fibrosis and tumor growth.These effects are related to a large number of transcription factors and transcriptional co-regulators that interact with Ski by many signaling pathways.Therefore,this article will introduce the regulatory roles and mechanisms of Ski in cell proliferation,transformation,collagen secretion and inflammatory.

关 键 词：SKI 增殖 细胞转化 胶原分泌 炎症 

分 类 号：R346[医药卫生—基础医学]