Synthesis of 4-aminoantipyrine Schiff bases and their antimicrobial activities  

作　　者：Olatunde S.Oladeji Monisola I.Ikhile Carine M.D.Fotsing Messai Mamo Patrick G.Ndungu Derek T.Ndinteh 

机构地区：[1]Department of Applied Chemistry, Faculty of Science, University of Johannesburg

出　　处：《Journal of Chinese Pharmaceutical Sciences》2018年第11期753-766,共14页中国药学（英文版）

基　　金：supported by the Faculty of Science,Department of Applied Chemistry;the University of Johannesburg for providing enabling environment to perform this work;the National Research Foundation(NRF)for the provision of running cost of this work

摘　　要：Various compounds of 4-aminoantipyrine Schiff bases(M1–M12) were synthesized via a condensation reaction of 4-aminoantipyrine with different benzaldehydes through a conventional method of refluxing the mixture for 3–4 h. The synthesized Schiff bases were characterized by using elemental analyses, FT-IR, UV-Vis, Mass, 1 H and 13 C NMR spectroscopy. The antimicrobial activity of the synthesized Schiff bases was investigated against 12 bacterial strains(Mycobacterium smegmatis, Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Klebsiella pneumonia, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Proteus vulgaris, Enterobacter aerogenes, and Pseudomonas aeruginosa), and antifungal activities were tested against seven fungal strains(Aspergillus flavus, Aspergillus carbonarious, Aspergillus parasiticus, Aspergillus fumigatus, Aspergillus niger, Fusarium verticillioides and Fusarium proliferatum). The antimicrobial activities of the synthesized compounds were compared with standard streptomycin and nalidixic acid. The results obtained from antibacterial assay indicated that M1–M12 inhibited potential growth of Proteus vulgaris with minimum inhibitory concentrations(MICs) ranging from 15.6–250 μg/mL compared with the standard nalidixic acid with an MIC of 500 μg/mL. Moreover, we could conclude that most of the tested compounds experienced mild to low activities at 15.6 μg/mL. Their activities could be attributed to their low concentration s. The antifungal analysis showed that the tested fungi were not sensitive to the prepared Schiff bases at the prepared concentration of 500 μg/mL. Therefore, we recommended further analysis on both cytotoxicity and minimum bactericidal concentration(MBC) to ascertain their potential effects against human cells.Various compounds of 4-aminoantipyrine Schiff bases(M1–M12) were synthesized via a condensation reaction of 4-aminoantipyrine with different benzaldehydes through a conventional method of refluxing the mixture for 3–4 h. The synthesized Schiff bases were characterized by using elemental analyses, FT-IR, UV-Vis, Mass, 1 H and 13 C NMR spectroscopy. The antimicrobial activity of the synthesized Schiff bases was investigated against 12 bacterial strains(Mycobacterium smegmatis, Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Klebsiella pneumonia, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Proteus vulgaris, Enterobacter aerogenes, and Pseudomonas aeruginosa), and antifungal activities were tested against seven fungal strains(Aspergillus flavus, Aspergillus carbonarious, Aspergillus parasiticus, Aspergillus fumigatus, Aspergillus niger, Fusarium verticillioides and Fusarium proliferatum). The antimicrobial activities of the synthesized compounds were compared with standard streptomycin and nalidixic acid. The results obtained from antibacterial assay indicated that M1–M12 inhibited potential growth of Proteus vulgaris with minimum inhibitory concentrations(MICs) ranging from 15.6–250 μg/mL compared with the standard nalidixic acid with an MIC of 500 μg/mL. Moreover, we could conclude that most of the tested compounds experienced mild to low activities at 15.6 μg/mL. Their activities could be attributed to their low concentration s. The antifungal analysis showed that the tested fungi were not sensitive to the prepared Schiff bases at the prepared concentration of 500 μg/mL. Therefore, we recommended further analysis on both cytotoxicity and minimum bactericidal concentration(MBC) to ascertain their potential effects against human cells.

关 键 词：4-AMINOANTIPYRINE ANTIBACTERIAL SCHIFFBASES ANTIFUNGAL SYNTHESIS INHIBITION 

分 类 号：R916[医药卫生—药学]