右美托咪定对膀胱肿瘤电切患者导尿管所致不适的预防  

Prevention Effect of Intraoperative Dexmedetomidine on Postoperative Catheter-Related Bladder Discomfort in Patients Undergoing Transurethral Bladder Tumor Resection

作　　者：朱亚娟[1] 毛一群[1] ZHU Ya-juan;MAO Yi-qun(Department of Anesthesiology,First Affiliated Hospital of Soochow University,Suzhou,Jiangsu,215006,China)

机构地区：[1]苏州大学附属第一医院麻醉科,江苏苏州215006

出　　处：《中国血液流变学杂志》2018年第2期170-172,231,共4页Chinese Journal of Hemorheology

摘　　要：目的观察右美托咪定对膀胱肿瘤电切患者导尿管所致不适的预防效果。方法将78例ASA Ⅰ-Ⅱ级择期全麻下行经尿道膀胱肿瘤电切术的患者随机分为两组:生理盐水组(C组,n=39),右美托咪定组(D组,n=39)。两组患者均行常规全麻诱导,手术开始时,D组予以右美托咪定0.5μg/kg,10min内静脉泵注,C组予以等量生理盐水泵注。记录两组患者泵注前、泵注后的收缩压、舒张压、心率、手术时间以及拔管时间,并记录术后1h及术后6h患者导尿管所致不适严重程度、发生率以及患者镇静程度。结果与C组相比,D组患者术后1h及6h导尿管相关不适严重程度明显减轻,且发生率显著降低(33.3%vs 56.4%,56.4%vs 79.5%,P均<0.05);D组患者在术后1h镇静程度偏深,术后6h两组间镇静程度差异无统计学意义。结论右美托咪定可以显著减轻膀胱肿瘤电切患者术后导尿管相关不适的严重程度并降低其发生率,同时不显著增加其他副作用。Objective To observe the prevention effect of intraoperative dexmedetomidine administration on postoperative catheter-related bladder discomfort (CRBD)in patients undergoing transurethral bladder tumor resection.Methods 78ASA Ⅰ -Ⅱ patients undergoing transurethral bladder tumor resection were randomly divided into two groups:saline group (group C,n=39)and dexmedetomidine group (group D,n=39).Both groups were induced by routine general anesthesia.At the beginning of the operation,group D was given dexmedetomidine 0.5μg/kg,intravenously in 10 minutes,and group C was given the same amount of saline pumping.The systolic pressure,diastolic pressure and heart rate were recorded before and after pumping in both groups.The time of operation and extubation were also recorded.The incidence and severity of CRBD and sedation level were assessed 1h and 6h after extubation.Results At 1h and 6h after extubation,the incidence and severity of CRBD in group D were significantly reduced compared with that of group C (33.3% vs 56.4%, 56.4%vs 79.5%,all P <0.05).At 1h,dexmedetomidine induce deeper sedation in group D,while at 6h, there was no difference between the two groups.Conclusion The injection of dexmedetomidine (0.5μg/kg) intraoperatively reduced the incidence and severity of CRBD and without causing significant side effects.

关 键 词：右美托咪定 膀胱肿瘤电切术 导尿管相关不适 

分 类 号：R614[医药卫生—麻醉学]