灯盏生脉胶囊对急性脑梗死患者血管内皮功能、氧化应激、血脂的影响及临床疗效评价  

Efficacy of Dengzhan Shengmai capsule on oxygen free radical scavenging,vascular endothelial function and blood lipid in patients with acute cerebral infarction

作　　者：黄攀 徐敏 何晓英 Huang Pan;Xu Min;He Xiaoying(People's Hospital of DEYANG City,Deyang 618000;People's Hospital of DEYANG City,The second People Hospital of DEYANG City,Deyang 618000;The Affiliated Hospital of Southwest Medical University,LuZhou 646000)

机构地区：[1]德阳市人民医院,德阳618000 [2]德阳市第二人民医院,德阳618000 [3]西南医科大学附属医院,泸州64600

出　　处：《中药药理与临床》2018年第5期124-128,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家"十一五"科技支撑计划重大专项基金资助项目(2006BAI04A02);四川省应用基础研究计划项目(14JC0166)

摘　　要：目的:观察灯盏生脉胶囊对急性脑梗死患者血管内皮功能、氧化应激、血脂相关指标的影响并评价其临床疗效。方法:选取我院2015年1月至2017年12月收治的急性脑梗死患者186例包括观察组与对照组各93例。对照组按照急性脑梗死治疗原则给予常规治疗,观察组在对照组基础上给予灯盏生脉胶囊进行治疗。观察两组治疗前与治疗后血管内皮功能指标内皮型NO合成酶(eN OS)、内皮素-1(ET-1)、血管性假性血友病因子(vW F),氧化应激指标超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶活性(GSH-Px),血脂指标总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)的变化差异,同时比较两组患者的临床治疗效果及不良反应情况。结果:观察组治疗后的总有效率为91.38%,显著高于对照组的79.55%;观察组与对照组不良反应率分别为9.7%、6.5%,无差异;治疗后,对照组TG、TC、LDL-C水平分别为(2.83±0.28、6.72±0.46、3.75±0.46)mmol/L显著高于观察组(2.72±0.27、6.36±0.41、3.53±0.41)mmol/l,而对照组HDL-C水平为(0.91±0.16)mmol/L显著低于观察组(1.09±0.18)mmol/L;治疗后,对照组ET-1、vW F水平分别为(73.64±8.24)pg/ml、(126.59±13.65)%显著高于观察组(68.31±7.45)pg/ml、(108.47±11.54)%,而对照组eN OS水平为(18.56±4.35)ug/L显著低于观察组(19.91±4.41)ug/L;治疗后,对照组MDA、GSH-Px分别为(7.26±1.34)umol/L、(48.32±12.52)mmol/L)显著高于观察组的(6.59±1.28)umol/L、(41.15±10.86)mmol/L),而对照组SOD水平为(55.12±5.85)uU/L显著低于观察组(62.34±5.72)uU/L;治疗后,对照组NIHSS评分为(13.21±3.82)分显著高于观察组(11.39±3.46)分,而对照组ADL评分为(59.31±7.10)分显著低于观察组(62.54±7.53)分。结论:灯盏生脉胶囊治疗急性脑梗死效果良好,其机制可能是通过调控血管内皮细胞功能、氧化应激反应及血脂的途径实现,且不会明显增加患者�Objective:To study the efficacy of Dengzhan Shengmai capsule on oxygen free radical scavenging,vascular endothelial function and blood lipid in acute cerebral infarction patients.Methods:186 patients with acute cerebral infarction collected from Jan 2015 to December2017,were randomly divided into Observation group and Control group,93 cases per group.Patients in the control group were given routine treatment.Patients in the observation group were given Dengzhan Shengmai capsule.After the treatment,the clinical efficacy,endothelial nitric oxygen synthase(e NOS),endothelin-1(ET-1),von Willebr and factor(v WF),super Oxide Dismutase(SOD),Malonaldehyde(MDA),Glutathione peroxidase(GSH-Px),Triglyceride(TG),Total cholesterol(TC),High density lipoprotein(HDL-C),low density lipoprotein(LDL-C),the plate area and adverse drug reaction were compared between two groups.Results:The total effective rate in the observation group was 91.38%,which was significantly higher than that in the control group(79.55%)(P<0.05).The adverse reaction rates in the observation group and the control group were 9.5% and 6.2% respectively,with no statistical significance(P>0.05).After the treatment,the levels of TG,TC and LDL-C in the control group were(2.83±0.28,6.72±0.46,3.75±0.46) mmol/L,higher than those in the observation group(2.72±0.27,6.36±0.41,3.53±0.41) mmol/L,while the HDL-C level in the control group was(0.91±0.16) mmol/L,significantly lower than that in the observation group(1.09±0.18) mmol/L(P<0.05).After the treatment,the levels of ET-1 and v WF in the control group were(73.64±8.24,126.59±13.65) pg/ml respectively,higher than those in the observation group(68.31±7.45,108.47±11.54) pg/ml,while The e NOS level in the control group was(18.56±4.35) ug/L,lower than that in the observation group(19.91±4.41) ug/L,the difference was statistically significant(P<0.05).After the treatment,MDA and GSH-Px in the control group were(7.26±1.34,48.32±12.52) mmol/L,higher than those in the observation group(6.59±1.28,41.15±10.86) mmo

关 键 词：灯盏生脉胶囊 急性脑梗死 氧化应激 血管内皮功能 血脂 

分 类 号：R277.7[医药卫生—中医学]