脂肪代谢障碍与抗炎治疗策略  

Adipose metabolic disorder and anti-inflammation therapy strategy

作　　者：徐春阳 李文兰[1] 杨秀颖 强桂芬 杜冠华[2] Xu Chunyang;Li Wenlan;Yang Xiuying;Qiang Guifen;Du Guanhua(Haerbin University of Commerce,Heilongjiang Province,Haerbin 150076;Beijing Key Laboratory of Drug Target and Screening Re-search,Institute of Materia Medica,Chinese Academy of Medical Science,Beijing 100050)

机构地区：[1]哈尔滨商业大学中药学院,哈尔滨150076 [2]北京协和医学院中国医学科学院药物研究所药物靶点研究与新药筛选北京市重点实验室,北京100050

出　　处：《中药药理与临床》2018年第5期168-172,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金资助项目(81770847);中国医学科学院创新工程重大协同创新项目(2017-I2M-1-010)。

摘　　要：肥胖是白色脂肪组织过度堆积导致稳态失衡,脂肪代谢出现障碍,进而引起全身的低度慢性炎症,全球发病率呈逐年增加的趋势。脂肪代谢障碍与炎症的发生发展可进一步引发胰岛素抵抗、2型糖尿病等代谢综合征及心脑血管疾病、癌症等并发症。本文就脂肪代谢障碍与抗炎治疗策略进行归纳与总结,从纠正脂肪代谢障碍,减轻炎症的角度出发,综合运用非药物治疗、靶向抗炎治疗、天然产物抗炎治疗及中医辨证施治等手段,或将改善慢性炎症,从而减轻肥胖、胰岛素抵抗、2型糖尿病等代谢综合征,对减轻代谢综合症患者的经济负担和病痛具有重要的意义。Obesity is systemic low-grade chronic inflammation caused by adipose homeostasis imlsalanee and metabolic disorder induced by white adipose tissue accumulation.The morbidity kept increasing worldwide.The adipose metabolic disorder and inflammation lead to metabolic syndrome such as insulin resistance and type 2diabetes,cardio-cerebrovaseular diseases and cancer.This review will summarize the therapy strategy of adipose metabolic disorder and anti-inflammation.Based on adipose metabolic disorder and anti -inflammation strategy,the nondrug clinical treatment,anti-inflammation targeted therapy,natural product anti-inflammation therapy and traditional Chinese medicine therapy will be beneficial for ameoliating chronic inflammation,subsequently alleviate obesity and insulin resistance and type 2diabetes.In addition,it has important significance in reducing the economic burden and suffering of metabolic syndrome patients.

关 键 词：肥胖 脂肪 脂肪代谢障碍 炎症 抗炎治疗 

分 类 号：R589.2[医药卫生—内分泌]