Th1、Th2、Th17相关细胞因子在甲状腺相关眼病中的作用机制  

Mechanism of Th1, Th2, Th17 related cytokines in thyroid-associated ophthalmopathy

作　　者：王丙玉 孙建平[1] 段薇[1] Wang Bingyu;Sun Jianping;Duan Wei(Department of Endocrinology,The Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,China)

机构地区：[1]大连大学附属中山医院内分泌科,116001

出　　处：《国际内分泌代谢杂志》2018年第6期394-396,408,共4页International Journal of Endocrinology and Metabolism

基　　金：2018年大连市医学科学研究计划项目(1811104).

摘　　要：甲状腺相关眼病(TAO)是自身免疫紊乱、遗传、环境等多因素共同影响的器官特异性自身免疫性疾病.辅助性T细胞(Th)1、Th2、Th17相关细胞因子在TAO中发挥重要的作用.新近研究表明,Tim3/Gal9通路、miRNA-146a以及过氧化物酶体增殖物活化受体-γ都可在Th1/Th2分化、增殖方面起关键作用.Th17分泌的白细胞介素-17,有致病性和非致病性两种,调控Th17可以改善TAO的进展。Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease which involves a variety of pathogenic factors such as autoimmune disorders,heredity and environment.Thelper cell(Th)1,Th2 and Th17 related cytokines play vital roles in TAO.The lately research shows that Tim3/Gal9 pathway,miRNA-146a and peroxisome proliferator-aetivated receptor-γ play key roles in Th1/Th2 differentiation and proliferation.Th17 can secrete interleukin-17,which is both pathogenic and nonpathogenic.The regulation of Th17 differentiation may improve the progression of TAO.

关 键 词：TH1 TH2 TH17 细胞因子 甲状腺相关眼病 

分 类 号：R581[医药卫生—内分泌] R771.3[医药卫生—内科学]