外周血25-羟维生素D3水平与婴幼儿毛细支气管炎的相关性分析  

The correlation between the serum 25-hydrovitamin D3 level and bronchiolitis in children

作　　者：袁林[1] 肖秀香 林建成 郭丹萍[1] 卓志强[1] Yuan Lin;Xiao Xiuxiang;Lin Jiancheng;Guo Danping;Zhuo Zhiqiang(Department of Respiratory,Children's Hospital of Fudan University Xiamen Branch (Xiamen Children's Hospital),Xiamen 361006,China)

机构地区：[1]复旦大学附属儿科医院厦门分院(厦门市儿童医院)呼吸科,厦门361006

出　　处：《中国小儿急救医学》2018年第11期839-842,共4页Chinese Pediatric Emergency Medicine

基　　金：厦门市科技局科技惠民项目(3502220164069).

摘　　要：目的 探讨外周血25-羟维生素D3[25-(OH)D3]水平与婴幼儿毛细支气管炎的关系及临床意义.方法 以2016年9月至2017年6月在厦门市儿童医院呼吸科住院的61例毛细支气管炎患儿为研究对象,同时选取同期同年龄健康体检儿童41例为健康对照组,记录毛细支气管炎组患儿相应临床资料,同时采用抗感染、雾化等综合治疗,全部儿童均采用酶联免疫吸附法检测血清25-( OH) D3水平以及血清IgE、IgG、IgA、IgM含量,比较各组检测结果 .结果 (1)与健康对照组比较,毛细支气管炎组患儿血清25-(OH)D3[(59. 47 ± 23. 66)nmol/L比(69. 94 ± 25. 19)nmol/L] 、IgM[(1. 27 ± 0. 49) g/L比(1.56 ±0.43)g/L]和IgA[(1.38 ±0.83)g/L比(1.71 ±0.61)g/L]水平明显下降,而血清IgE [(106. 59 ±67. 74)IU/L比(75. 95 ±35. 27)IU/L]明显升高,差异均有统计学意义(P<0. 05). (2)维生素D缺乏组毛细支气管炎患儿的IgE[(177. 37 ± 82. 72)IU/L]表达水平明显高于维生素D不足组[(94.21 ±44.21)IU/L]和正常组患儿[(79.60 ±44.30)IU/L],同时IgG和IgA[(5.46 ±1.95)g/L和(0.68 ±0.24)g/L]表达水平明显低于维生素D不足组[(7.14 ±2.82)g/L和(1.35 ±0.72)g/L]和正常组患儿[(8.03 ±2.49)g/L和(1.57 ±0.78)g/L],差异均有统计学意义(P<0.05).维生素D不足组和正常组患儿血清IgE、IgG、IgA、IgM差异均无统计学意义(P>0. 05). (3)维生素D缺乏组毛细支气管炎患儿的临床症状中,喘息持续时间[(3. 97 ± 1. 01)d]明显长于维生素D不足组[(2. 41 ± 0. 79) d]和正常组患儿[( 2. 27 ± 0. 88 ) d],静脉激素使用率明显高于维生素 D 正常组患儿( 58. 82% 比29. 03%),差异均有统计学意义(P<0. 05);维生素D不足组和正常组患儿各项临床资料比较差异均无统计学意义(P>0. 05).结论 毛细支气管炎患儿血清维生素D水平低于正常同龄儿童,维生素D水平和毛细支气管炎的病情严重程度存在相关性,维生素D缺乏导致免疫功能紊乱可能是儿童罹患毛细支气管炎的重要�Objective To investigate the correlation and clinical significance between the serum 25-hydrovitamin D3[25-(OH)D3] level and bronchiolitis in children.Methods Sixty-one children with bronchiolitis diagnosed by Xiamen Children's Hospital between September 2016 and June 2017 were enrolled in the study.Forty-one healthy children were used as the healthy control group.All the children were tested by enzyme-linked immunosorbent assay for serum 25-(OH)D3 levels and serum IgE,IgG,IgA and IgM content. The clinical data of children with bronchiolitis group were recorded in the meanwhile.Results (1)Compared with the healthy control group,the serum levels of 25-(OH)D3[(59.47±23.66)nmol/L vs.(69.94±25.19)nmolfL],IgM[(1.27±0.49)g/L vs.(1.56±0.43)g/L]and IgA[(1.38±0.83)g/L vs.(1.71±0.61)g/L]were significantly lower in children with bronchiolitis ;while the serum IgE [(106.59±67.74) IU/L vs.(75.95±35.27)IU/LI was significantly higher(P <0.05).(2)The serum levels of IgE,IgG and IgA in children diagnosed bronchi01itis with vitamin D deficiency [(177.37±82.72)IU/L,(5.46±1.95)g/L and (0.68±0.24)g/L ]were obviously different from those of children diagnosed bronchiolitis with vitamin D inadequate [(94.21±44.21)IU/L,(7.14±2.82)g/L and (1.35±0.72)g/L ]and vitamin D normal group [(79.60±44.30)IU/L,(8.03±2.49)g/L and (1.57±0.78)g/L ](P <0.05).There was no significant difference about serum levels of IgE,IgG,IgA and IgM between vitamin D inadequate and vitamin D normal group (P >0.05).(3)The wheeze time was higher in bronchiolitis children with vitamin D deficiency [(3.97±1.01)d ]than those of patients with vitamin D inadequate [(2.41±0.79)d ]and vitamin D normal group [(2.27±0.88)dl (P <0.05).The level of venous glucocorticoid utilization was higher in bronchiolitis children with vitamin D deficiency than that of patients with vitamin D normal group (58.82%vs.29.03%)(P <0.05).There was no significant difference about clinical data between vitamin D inadequate and vitamin D normal group (P>0.05).Conclusion The serum 2

关 键 词：25-羟维生素D3 毛细支气管炎 儿童 

分 类 号：R725.6[医药卫生—儿科]