冠心病痰瘀互结证SAQ与生化指标相关研究  

Correlation between SAQ and Biochemical Indexes of Coronary Heart Disease With Phlegm And Blood Stasis Syndrome

作　　者：冯曼 梁如[1] 邓兵[2] 毛美娇[2] 杜廷海[3] 李彬[3] 杨宝平[4] 于研 张虹[5] 张世姝[5] 毛静远[6] 王贤良[6] 徐强[7] 张蕾 宋光明[8] 田莉 王丽[9] 边育红[1] 闫丹丹 高杉[1] 李琳[1] 潘晔[1] 蔡雪朦 步怀恩[1] 高树明[1] 李先涛[10] 徐一兰[1] 于春泉[1] FENG Man;LIANG Ru;DENG Bing;MAO Mei-jiao;DU Ting-hai;LI Bin;YANG Bao-ping;YU Yan;ZHANG Hong;ZHANG Shi-shu;MAO Jing-yuan;WANG Xian-liang;XU Qiang;ZHANG Lei;SONG Guang-ming;TIAN Li;WANG Li;BIAN Yu-hong;YAN Dan-dan;GAO Shan;LI Lin;PAN Ye;CAI Xue-meng;BU Huai-en;GAO Shu-ming;LI Xian-tao;XU Yi-lan;YU Chun-quan(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China;Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;The First Affiliated Hospital of Henan University of.TCM,Zhengzhou 136300,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730699,China;Tianfin Hospital of ITCWM Nankai Hospital,Tianjin 300100,China;First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300150,China;Affiliated Wuqing Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 301700,China;Tianjin Second People's Hospital,Tianjin 300192,China)

机构地区：[1]天津中医药大学,天津300193 [2]上海中医药大学附属龙华医院,上海200032 [3]河南中医药大学第一附属医院,郑州136300 [4]甘肃省中医院,兰州730699 [5]天津市南开医院,天津300100 [6]天津中医药大学第一附属医院,天津300193 [7]天津中医药大学第二附属医院,天津300150 [8]天津市武清区中医医院,天津301700 [9]天津市第二人民医院,天津300192 [10]广州中医药大学,广州510006

出　　处：《中国中医基础医学杂志》2018年第11期1554-1557,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家重点基础研究计划(973计划)项目(2014CB542902)-冠心病痰瘀互结证病证方对应关系的临床研究

摘　　要：目的:旨在对冠心病稳定型心绞痛痰瘀互结证和气阴两虚证患者不同时点的SAQ和生化指标进行相关性分析并探究二者的相关性。方法:采用多中心、小样本、精细化的研究方法记录冠心病患者SAQ积分,并检测脂质代谢、炎症介质、金属蛋白酶、同型半胱氨酸等7类28项指标,检测时点为0、8、12周,对SAQ进行聚类分析并与生化指标进行相关性分析。结果:聚类与主成分分析得出,痰瘀互结证以躯体活动受限程度、脂质代谢和炎症介质指标为主要参考标准,气阴两虚证以治疗满意程度和疾病认知程度、炎症介质和凝血功能指标为主要参考标准。结论:SAQ与生化指标的联合应用,对于临床冠心病痰瘀互结证和气阴两虚证的判定具有一定的指导作用。Objective: The aim of this study is to analyze the correlation between SAQ and biochemical indexes at different time points in patients of phlegm and blood stasis syndrome and qi-yin deficiency syndrome in coronary artery disease with stable angina pectoris. Methods: This study adopted the multi-center,small sample and refined method,the SAQ scores of patients with coronary heart disease were recorded, and lipid metabolism, inflammatory mediators,metalloproteinases,homocysteine and other seven categories of 28 indicators were detected at 0,8,12 weeks. Cluster analysis was performed on SAQ and correlation analysis was conducted with biochemical indexes. Results: The results of clustering and principal component analysis show: The phlegm and blood stasis syndrome of physical activity,lipid metabolism and inflammatory mediators were the main reference indicators. The qi-yin deficiency syndrome as the main reference standard for treatment satisfaction and disease awareness,inflammatory mediators and coagulation function indicators. Conclusion: The combined application of SAQ scale and biochemical indicators has a certain guiding role in the phlegm and stasis syndrome and qi-yin deficiency syndrome of coronary heart disease with stable angina pectoris.

关 键 词：冠心病稳定型心绞痛 痰瘀互结证 西雅图心绞痛量表 生化指标 

分 类 号：R541.4[医药卫生—心血管疾病]