猪传人重症乙型流行性感冒并肺炎1例及文献复习  

Swine-spread severe influenza-associated pneumonia: A case report and literature review

作　　者：刘婷 姜亚峰 欧阳若芸[1] LIU Ting;JIANG Yafeng;OUYANG Ruoyun(Department of Pulmonary and Critical Care Medicine,Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院呼吸与危重症医学科,长沙410011

出　　处：《中南大学学报（医学版）》2018年第11期1266-1271,共6页Journal of Central South University ：Medical Science

基　　金：国家临床重点专科建设项目(2012-650)~~

摘　　要：报告1例由猪传人引起乙型流行性感冒病毒(influenza B virus,IBV)感染所致重症肺炎的临床资料,并对相关文献进行复习。患者为男性,62岁,家猪饲养员,发热、全身肌肉疼痛5 d,气促3 d入院。发病1周有病猪接触史,CT示双肺弥漫性渗出灶,多次咽拭子IBV抗原检测(胶体金法)阳性,IBV感染诊断明确。病猪食欲差、消瘦、咳嗽、精神差,咽拭子IBV抗原检测(胶体金法)阳性,患者无IBV感染者接触史,由此推断病猪经飞沫或接触传播至患者,引起IBV感染。IBV5～6年局部流行一次,患者及隐性感染者为主要传染源。检索PubMed,Web of Science,Elsevier,万方及CNKI数据库后发现,虽有IBV感染海豹、雪貂、家猪、豚鼠等动物报道,但并无动物与人交叉传播病例见报,本例猪传人引起IBV感染病例报告为IBV研究及流行防治提供了新方向。We report and analyze the clinical data of the first case of severe pneumonia caused by influenza B virus from swine. Th e patient, a 62 year-old male domestic pig breeder, was admitt ed to hospital because of fever and muscle pain for 5 days, and anhelation for 3 days. One week before the onset of disease, the patient kept close contact with pigs. CT scan of the chest showed diff use infiltration in both lungs. Influenza B virus antigen detection(colloidal gold method) was repeatedly positive. These all confirmed influenza B virus infection. Poor appetite, weight loss, cough, poor spirit of pigs, positive influenza B virus antigen test occurred in the pig, while the patient had no history of exposure to influenza B-infected patients. It was likely that influenza B virus was transmitted from domestic pigs to the patient by droplets or close contact. Influenza B virus epidemics always occur every five or six years a time, and patients and carriers are the main source of infection. After searching the Pubmed, Web of science, Elsevier, Wanfang, and CNKI databases, it was found that although there were many studies on influenza B virus infecting seals, ferret, domestic pigs, guinea pigs, and other animals, there was no case report for animal-to-human infection. It is the first case report of type B influenza virus transmission from domestic pigs to people in the world, which provides a new direction for the research and prevention of influenza B virus.

关 键 词：乙型流行性感冒病毒 传播途径 流行性感冒 防治 

分 类 号：R511.7[医药卫生—内科学] R563.1[医药卫生—临床医学]