耐药时代下新型抗菌天然产物的发现策略  

Strategies for discovery of novel antibacterial natural products under the antibiotic crisis

作　　者：何艳 周群[2] 胡正喜[2] 张锦文[1,2] 张勇慧[2] HE Yan;ZHOU Qun;HU Zheng-xi;ZHANG Jin-wen;ZHANG Yong-hui(Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030)

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030 [2]天然药物化学与资源评价湖北省重点实验室,华中科技大学同济医学院药学院,武汉430030

出　　处：《中南药学》2018年第11期1579-1583,共5页Central South Pharmacy

基　　金：教育部长江学者奖励计划(No.T2016088);国家杰出青年科学基金(No.8172500151);国家自然科学基金委创新群体项目(No.81721005);国家自然科学基金青年基金项目(No.8180130778);湖北省自然基金面上项目(No.2018CFB152)

摘　　要：天然产物及其衍生物是抗菌药物发现的主要来源,但现今细菌耐药性的加剧给其研发带来巨大挑战。新抗菌药物的发现速度远低于细菌耐药产生的速度。21世纪以来,基因组学的创新和新抗菌资源的开发、对已知天然产物价值的重新认识以及抗菌辅佐剂的开发、组合生物合成等新研发策略的发展,为临床提供了大量新的抗菌先导化合物。天然产物化学结构具有多样性,在目前细菌耐药日趋严重的情况下,天然产物在抗菌新药研发中占据重要地位。Natural products and their derivatives are main sources for the discovery of antibiotic drugs, however, nowadays the intensification of bacterial resistance imposes a huge challenge for their research and development. At the same time, the rate for new antibiotics discovery is much slower than that of bacterial drug resistance. Since the 21 st century, the advancement of several new methods, including new technologies such as the innovation of genomics and development of new antibacterial resources, repurposed the known natural products, and combinatorial biosynthesis etc., have brought new life to natural products and also provided new antibacterial lead compounds for clinical practice. The chemical structures of natural products are characterized by diversity and novelty. Under the current antibiotic crisis, natural products will regain its dominance in the development of new drugs.

关 键 词：天然产物 抗菌药物危机 新研发策略 抗菌新药 抗菌辅佐剂 组合生物合成 

分 类 号：R978.5[医药卫生—药品]