神经炎症在锰中毒中的作用及对氨基水杨酸钠对其治疗作用研究进展  

Research progress in role of neuroinflammation in manganese poisoning and therapeutic effects of sodium 4-aminosalicylate

作　　者：梁典胤 谢秉言 许放[1] 姜岳明[1] LIANG Dian-yin;XIE Bing-yan;XU Fang;JIANG Yue-ming(Department of Health Toxicology,School of Public Health,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学公共卫生学院卫生毒理学教研室,广西南宁530021

出　　处：《中国药理学与毒理学杂志》2018年第7期579-584,共6页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81460505)~~

摘　　要：实验研究发现,过量锰暴露能刺激神经系统产生大量的炎症因子,发生炎症反应,以至神经中毒表现加重。流行病学调查显示,长期慢性锰暴露能引起神经功能紊乱,可能与帕金森病、阿尔茨海默病的发生关系密切。神经炎症是锰中毒及其他神经退行性疾病重要的致病机制,小胶质细胞和星形胶质细胞功能失衡与神经炎症的发生发展密切相关。对氨基水杨酸钠不仅有螯合金属的特性,而且有非特异性抗炎作用,可能对锰中毒性神经炎症有治疗作用,对锰中毒治疗有积极意义。Experimental studies have found that chronic manganese exposure can stimulate the nervous system to produce a large number of inflammatory factors, inflammatory reaction, and aggravation of neurotoxicity. Epidemiological investigations show that chronic manganese exposure can cause neurological dysfunction, which may be closely related to the occurrence of Parkinson disease and Alzheimer disease. Neuroinflammation is an important pathogenic factor in manganese poisoning and other neurodegenerative diseases. The dysfunction of microglia and astrocytes is closely related to the induction and development of neuroinflammation. Sodium 4-aminosalicylate has not only the properties of chelating metals, but also nonspecific anti-inflammatory effects. It may have antagonisrn on manganese toxic neuroinflammation and positive significance for the trentment of manganese poisoning.

关 键 词：锰中毒 神经炎症 对氨基水杨酸钠 

分 类 号：R99[医药卫生—毒理学]