含单氟甲氧基的双酰胺类化合物的合成及杀虫活性  

Synthesis and insecticidal activities of diamides containing monofluoromethoxy group

作　　者：张冬林 杨森 杨忍 裴丹 张帆 刘杰[1] 李建业 谭成侠[1] ZHANG Donglin;YANG Sen;YANG Ren;PEI Dan;ZHANG Fan;LIU Jie;LI Jianye;TAN Chengxia(College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310004,China)

机构地区：[1]浙江工业大学化学工程学院

出　　处：《农药学学报》2018年第6期715-720,共6页Chinese Journal of Pesticide Science

基　　金：“十二五”国家科技支撑计划资助项目(2011BAE06B01-20)

摘　　要：以2,3-二氯吡啶为起始原料,经肼基化、环合、氧化、取代、水解、环合和胺解反应,合成了15个文献未见报道的新型含单氟甲氧基的吡唑邻甲酰氨基苯甲酰胺类化合物,其结构通过核磁共振氢谱和高分辨质谱确认。初步的杀虫活性测试结果显示,所有目标化合物在100mg/L下对粘虫Orientalarmyworm的致死率均为100%,当测试浓度降低至4mg/L时,化合物8a、8d、8g、8k和8n的致死率仍为100%,值得进一步研究。Fifteen novel diamides containing monofluoro methoxy group compounds were synthesized using 2,3-dichloropyridine as the starting material by hydrazinolysis,cyclization,oxidation, substitution,hydrolysis,cyclization and amine hydrolysis.The structures of the title compounds were characterized by 1H NMR and HRMS.Preliminary bioassay results indicated that all the target compounds showed insecticidal activities.At the concentration of 100mg/L,all compounds exhibited 100%insecticidal activities against Oriental armyworm.When the concentration was reduced to 4mg/L, compounds 8a,8d,8g,8k and 8n still exhibited 100%insecticidal activities against O.armyworm.

关 键 词：新农药创制 单氟甲氧基 双酰胺类杀虫剂 吡唑 杀虫活性 

分 类 号：O626[理学—有机化学] TQ453.2[理学—化学]