ALCAM在不同肿瘤中的表达及其作用  

Expression of ALCAM in Tumor Tissues and Its Roles

作　　者：刘怡然 陈亦斌 杨晓梅[2] LIU Yiran;CHEN Yibin;YANG Xiaomei(Clinical Medicine of Eight-Year Education,Capital Medical School,Beijing,100069,China;Department of Biochemisty and Molecular Biology,Basic Medical School,Capital Medical School,Beijing,100069,China)

机构地区：[1]首都医科大学16级长学制临床三班,北京市100069 [2]首都医科大学基础医学院生物化学与分子生物学系,北京市100069

出　　处：《医学分子生物学杂志》2018年第6期440-444,共5页Journal of Medical Molecular Biology

基　　金：首都医科大学长学制科研项目(No.7NZDS2017)。

摘　　要：活化白细胞黏附分子(activated leukocyte cell adhesion molecule,ALCAM),最早发现于转移性黑色素瘤细胞系,随之发现ALCAM在活化的T细胞、活化的单核细胞、上皮细胞和成纤维细胞等中均有表达。近年发现,ALCAM在胰腺癌、结肠癌、子宫颈癌、前列腺癌、卵巢癌和口腔鳞状细胞癌等多种肿瘤中的表达量较正常组织升高,与癌症进展有关,且参与肿瘤的浸润和转移,可被视作潜在的肿瘤细胞标志物。Activated letikocyte cell adhesion molecule (ALCAM)was first found in the meta-static melanoma cell line,and it was later demonstrated to be expressed in activated T cells,activated monocytes,epithelial cells and fibroblasts.In recent years,the expression of ALCAM in different tumors,such as pancreatic cancer,colorectal cancer,cervical cancer,prostate cancer,ovarian cancer and oral squamous cell carcinoma,is found to be higher than in normal tissues.It is related to the progression of cancer and is involved sidered as a potential marker of cancer cells. in tumor invasion and metastasis.It may be considered as a potential marker of cancer cells.

关 键 词：活化白细胞黏附分子 分子标记物 转移 

分 类 号：R34[医药卫生—基础医学]