补阳还五汤中红花药材的煎煮动力学模型的建立  

Establishment of Kinetic Model of Decoction of Carthamus Tinctorius L in Buyang Huanwu Decoction

作　　者：邓智月 王圣鑫 王利胜[1] DENG Zhiyue;WANG Shengxin;WANG Lisheng(College of Chinese Materia Medica,Guang,zhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China;Guangdong Province Hospital of Traditional Chinese Medical ,Guangzhou510120,Guangdong,China)

机构地区：[1]广州中医药大学中药学院,广东广州510006 [2]广东省中医院,广东广州510120

出　　处：《中华中医药学刊》2018年第12期2959-2961,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81373973,81573872)

摘　　要：目的:以补阳还五汤中羟基红花黄色素A的含量为考察指标,建立补阳还五汤中红花药材的煎煮动力学模型。方法:建立HPLC法测定补阳还五汤中羟基红花黄色素A含量;以Fick扩散定律为基础,推算出煎煮动力学参数并拟合方程。结果:羟基红花黄色素A在0.40~2.80μg之间,线性关系良好,回归方程:y=48.924X-1.3809R2=0.9998;煎煮动力学方程为CB=CB[0.01596/σ(MIR)t1/2]^1/6.3,且验证结果良好。结论:本次研究所建立的动力学模型能较好地与试验结果相吻合,各条件下的试验数值与计算数值的标准偏差(6.72%)基本能满足工业标准偏差要求。Objective :To determine the content of hydroxysafflor yellow A in Buyang Huanwu Decoctionand establish the decoction kinetic model of the Carthamus tinctorius L in Buyang Huanwu Decoction.Methods :The content of hydroxysafflor yellow A in Buyang Huanwu Decoction was determined by high performance liquid chromatography.Based on the fick diffusion law,the equation parameters were deduced and fitted.Results:Hydroxysafflor yellow A was between 0.40~2.80 μg.The linear relationship was good.The verification result was good.Conclusion.The kinetic model established in this study is in good agreement with the experimental results.The standard deviation (6.7225%)of the experimental values and the calculated values under each condition can basically meet the requirements of industrial standard deviation.

关 键 词：补阳还五汤 红花 羟基红花黄色素A 煎煮动力学模型 

分 类 号：R283[医药卫生—中药学]