以丹参为主要成分的中药注射剂改善心肌缺血症状的疗效对比  

Effect of Danshen Injection in Improving Symptoms of Myocardial Ischemia

作　　者：高宪玺 孙妍 弭澜 GAO Xianxi;SUN Yan;MILan(Cardiovascular Department One,Tangshan Center Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市中医医院心血管一科

出　　处：《中华中医药学刊》2018年第12期3036-3038,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省中医药管理局项目(2016210)

摘　　要：目的:以丹参为主要成分的中药注射剂在改善心肌缺血症状的疗效对比。方法:选取2016年8月-2017年8月收治的冠心病心肌缺血患者120例,随机分为A(丹参注射液)、B(丹红注射液)、C(丹参酮IIA磺酸钠注射液)3组,对比治疗前后血浆TXB2、6-K-PGF1α以及炎症因子CRP,比较3组患者临床症状有效率和心电图有效率。结果:3组治疗前TXB2、6-K-PGF1α、CRP水平差异无统计学意义(F=3.475、4.121、2.132,P>0.05),具有可比性;治疗后A组TXB2、6-K-PGF1α、CRP水平显著低于B组,差异有统计学意义(t=8.31、9.42、10.58,P<0.05);B组TXB2、6-K-PGF1α、CRP水平显著低于C组,差异有统计学意义(t=8.12,6.24,11.51,P<0.05);A、B、C 3组患者临床总有效率分别为90.0%、82.5%和72.5%,差异有统计学意义(q=3.792,P=0.014)。A组患者临床总有效率高于B、C组,B组者临床总有效率高于C组,差异均有统计学意义(P<0.05);A、B、C 3组患者心电图总有效率分别为85.0%、67.5%和55.0%,差异有统计学意义(q=4.581,P=0.008)。A组患者心电图总有效率高于B、C组,B组患者心电图总有效率高于C组,差异均有统计学意义(P<0.05)。结论:丹参制剂可抑制血小板聚集和炎症因子释放,改善心肌缺血临床症状和心电图表现,且以丹参注射液疗效最显著,其次为丹红注射液。Objective:To investigate the effect of Danshen Injection in improving the symptoms of myocardial ischemia.Methods:From August 2016 to August 2017 in our hospital 120 cases of myocardial ischemia with coronary heart disease were randomly divided into A(Danshen Injection), B(Danhong Injection), C(tanshinone IIA) groups. We compared plasma TXB2, 6-K-PGF1 alpha and inflammatory factor CRP, symptoms of efficiency and efficiency of ECG before and after treatment.Results:There was no significant difference in the three groups’ TXB2, 6-K-PGF1 and CRP alpha before treatment(F=3.475, 4.121, 2.132, P>0.05). After treatment, group A’s TXB2, 6-K-PGF1 alpha and CRP levels were significantly lower than those of B group, and the difference was statistically significant(t=8.31, 9.42, 10.58, P<0.05). Group B’s TXB2, 6-K-PGF1 a and CRP levels were significantly lower than those of C group, and the difference was statistically significant(t=8.12, 6.24, 11.51, P<0.05). A, B, C groups’ clinical total effective rate was 90%, 82.5% and 72.5%, and the difference was statistically significant(q=3.792, P=0.014). A group’s clinical total efficiency was higher than that of B, C groups. B group’s total clinical efficiency was higher than that of C group, and the differences were statistically significant(P<0.05). A, B and C groups’ electrocardiogram total effective rate was 85%, 67.5% and 55%, and the difference was statistically significant(q=4.581,P=0.008). The total effective rate of ECG in group A was higher than that in group B and group C, and the total effective rate of ECG in group B was higher than that in group C, and the difference was statistically significant(P<0.05). Conclusion:The preparation of Radix Salviae Miltiorrhizae can inhibit platelet aggregation and release of inflammatory factors, improve the clinical symptoms and ECG manifestations of myocardial ischemia, and the effect of Danshen Injection is most significant, followed by Danhong Injection.

关 键 词：丹参注射液 丹红注射液 丹参酮IIA磺酸钠注射液 心肌缺血 

分 类 号：R541.4[医药卫生—心血管疾病]