不明原因反复早期流产患者体内炎症相关因子的表达及其与HMGB1蛋白的相关性研究  

Relationship between the expression of inflammatory related factors and HMGB1protein in patients with unexplained recurrent early abortion

作　　者：董耘[1] 徐昕[2] 柯丽娜[1] 李斌[1] DONG Yun;XU Xin;KE Li-na(Department of Obstetrics and Gynecology,Dongfeng Hospital Affiliated to Hubei University of Medicine,Shiyan,Hubei 442000,China)

机构地区：[1]湖北医药学院附属东风总医院妇产科,湖北十堰442000 [2]湖北医药学院附属东风总医院骨科

出　　处：《中华全科医学》2018年第12期2039-2041,共3页Chinese Journal of General Practice

基　　金：2015—2016年度湖北省卫生计生西医类一般项目(WJ2015MB221)

摘　　要：目的探讨不明原因反复早期流产患者体内炎症相关因子的表达与HMGB1蛋白的相关性。方法选择2013年2月—2017年7月在湖北医药学院附属东风总医院产科门诊就诊的不明原因反复早期流产孕妇172例作为流产组,按照1∶1配比原则,选择同期参加正常孕期检查未发生不明原因反复早期流产的孕妇172例作为对照组,2组都抽取空腹静脉血进行炎症相关因子与HMGB1表达检测,同时进行相关性分析。结果流产组的血清IL-6、TNF-α、HMGB1含量分别为(49.22±10.39)pg/L、(82.49±10.11)pg/L和(99.02±21.49)ng/ml,都明显高于对照组的(27.33±9.82)pg/L、(30.19±6.88)pg/L和(47.99±10.53)ng/ml(均P<0.05)。Pearson分析显示流产组的血清IL-6、TNF-α都与HMGB1呈正相关(r=0.562、0.672,均P<0.05)。多因素条件Logistic回归分析显示,IL-6、TNF-α、HMGB1都为影响不明原因反复早期流产的主要危险因素(均P<0.05)。结论不明原因反复早期流产患者体内炎症因子IL-6、TNF-α与HMGB1都呈现高表达状态,且可互相影响,是流产发生的独立危险因素。Objective To investigate the correlation between the expression of inflammatory related factors and HMGB1 protein in patients with unexplained recurrent early abortion. Methods From February,2013 to July,2017,172 cases of pregnant women with unexplained recurrent early abortion were selected as abortion group,and the other pregnant women with not unexplained recurrent early abortion were selected as the control group accorded to the 1∶1 matching principle, the serum inflammation related factors and the expression of HMGB1 in the two groups were detected and were given correlation analysis. Results The serum IL-6,TNF-α and HMGB1 levels in the abortion group were ( 49. 22 ± 10. 39) pg /L,( 82. 49 ± 10. 11) pg /L and ( 99. 02 ± 21. 49) ng /ml that were significantly higher than the control group of ( 27. 33 ± 9. 82) pg /L,( 30. 19 ± 6. 88) pg /L and ( 47. 99 ± 10. 53) ng /ml ( P < 0. 05) . Pearson analysis showed that the serum IL-6,TNF-α were positive correlation to the HMGB1 in the abortion group( r = 0. 562,0. 672,P < 0. 05) . Multivariate Logistic regression analysis showed that IL-6,TNF-α and HMGB1 were the main risk factors of unexplained early recurrent spontaneous abortion ( P < 0. 05) . Conclusion The inflammatory factors IL-6,TNF-α and HMGB1 in the unexplained recurrent early abortion are showed high expression,and can influence each other,they are independent risk factors of spontaneous abortion.

关 键 词：不明原因反复早期流产 炎症因子 HMGB1 相关性 

分 类 号：R714.21[医药卫生—妇产科学] R446.11[医药卫生—临床医学]