肾脱细胞支架与再细胞化技术的研究进展  

Research advances in renal decellularized scaffolds and recellularization techniques

作　　者：耿光瑞 李清刚[1] 陈香美[1] GENG Guangrui;LI Qinggang;CHEN Xiangmei(State Key Laboratory of Kidney Diseases,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院肾脏疾病国家重点实验室,北京100853

出　　处：《解放军医学院学报》2018年第11期999-1003,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家重点研发计划项目(2016YFC1101403)~~

摘　　要：肾脱细胞支架是生物人工肾重要的材料支撑,理想的肾脱细胞支架应具备血管网络和独特的组织特异性结构,既有与天然组织相同的机械强度,又能提供微观和宏观的组织框架结构,利于细胞增殖分化,最终完成工程化的器官构建。本文就肾脱细胞支架的制作方法及质量评价、脱细胞支架再细胞化、肾生物打印技术、未来发展潜力及面临的挑战等做一综述,为未来实践提供参考。Renal decellularized scaffold is an important material supporting for bioartificial kidneys. Ideal renal decellularized scaffolds should have a vascular network and unique tissue-specific structure, as well as the same mechanical strength to natural tissue, and provide microscopic and macroscopic tissue frameworks. Renal decellularized scaffold can facilitate cell proliferation and differentiation, and finally complete the construction of engineered organs. This article reviews the preparation methods and quality evaluation of renal decellularized scaffolds, recellularization of decellularized scaffolds, kidney bioprinting technology, future development potential and challenges, and provides evidences for future practice.

关 键 词：生物人工肾 脱细胞支架 再细胞化 干细胞 生物打印 

分 类 号：R318.08[医药卫生—生物医学工程]