基于代谢组学针灸研究领域的文献计量学分析  

Bibliometric Analysis Based on Metabonomics in the Field of Acupuncture and Moxibustion

作　　者：张永怡[1] 孙志岭[1] 谢彤 焦文娟 何静[1] ZHANG Yong-yi;SUN Zhi-ling;XIE Tong;JIAO Wen-juan;HE Jing(School of Nursing,Nanjng University ofjTCM,Nanjing(210023);Medical Protemics Center.Nanjing University of TCM,Nanjing(210023))

机构地区：[1]南京中医药大学护理学院,南京210023 [2]南京中医药大学医学代谢组学中心,南京210023

出　　处：《中国中西医结合杂志》2018年第12期1449-1453,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金面上项目(No.81774383);2016年江苏省普通高校研究生科研创新计划学术型省立校助项目(No.KYLX16-1164);江苏省优势学科二期项目南京中医药大学护理学一级学科指令性课题(No.YSHL2016-016)

摘　　要：目的系统分析基于代谢组学针灸研究领域文献的基本信息、研究内容与研究方向。方法基于文献计量学的方法,检索各数据库建库以来至2017年8月针灸领域应用代谢组学技术的文献,中文数据库:中国知网、维普中文期刊数据库、万方全文数据库、中国生物医学文献数据库;外文数据库:Cochrane library、MEDLINE。使用文献计量学方法对检索出的文献进行归纳与总结。结果纳入文献67篇,其中英文文献11篇,中文文献56篇。文献包括综述类11篇(16.42%)、临床试验32篇(47.76%)、动物实验22篇(32.84%)与实验计划2篇(2.99%)。涉及疾病19种,以消化系统疾病为研究热点共25篇(包含功能性消化不良、肠易激综合征、溃疡性结肠炎等)。代谢组学检测技术主要是核磁共振技术35篇,检测样本主要为血浆28篇。结论代谢组学在中医药领域的应用十分广泛,但使用代谢组学技术分析针灸问题的研究相对较少,且起步较晚。先进的代谢组学技术与传统中医针灸疗法相结合,才能够更加科学的解释针灸的作用机制,促进针灸的科学发展。Objective To provide reference and guidance for using metabonomics in analyzing acupuncture research by analyzing basic information and research contents of literatures. MethodsBased on bibliometrics, database such as CNKI, VIP, Wanfang database, CBM, Cochrane Library, MEDLINE were retrieved from their establishment to August 2017. Literatures retrieved by bibliometrics were concluded and summarized. Results Totally 67 literatures were included,11 English literatures and 56 Chinese literatures. They covered reviews [11(16.42%)], clinical trials [32(47.76%)], animal experiments [22(32.84%)], and experimental programs [2(2.99%)]. Totally 19 kinds of diseases were involved. Totally 25 literatures were highlighted on digestive system diseases(including functional dyspepsia, irritable bowel syndrome, ulcerative colitis, and so on). There were 35 literatures using ~1H-NMR as main platform of metabonomics. There were 28 literatures using plasma as prime samples. Conclusions Metabolomics is widely used in the field of traditional Chinese medicine. However, studies on the analysis of acupuncture and moxibustion by using metabolomics technology are relatively few, and started late. Only by combining advanced metabolomic techniques with acupuncture and moxibustion therapy can the mechanism of acupuncture be explained more scientifically and the scientific development of acupuncture and moxibustion be promoted.

关 键 词：代谢组学 针灸 文献计量学 

分 类 号：R245[医药卫生—针灸推拿学] G353.1[医药卫生—中医临床基础]