异叶三宝木枝叶中一个新的Stemodane型二萜类化合物  

A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus

作　　者：刘艳萍[1,2] 张项林 牛海渊 官春艳 孙福康 杨柳萌[3] 付艳辉[1,2] Liu Yanping;Zhang Xianglin;Niu Haiyuan;Guan Chunyan;Sun Fukang;Yang Liumeng;Fu Yanhui(Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education,Hainan Normal University,Haikou 571158;Key Laboratory of Southern Medicinal Plants Resources of Haikou City,Hainan Normal University,Haikou 571158;Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Seiences,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223)

机构地区：[1]海南师范大学热带药用植物化学教育部重点实验室,海口571158 [2]海南师范大学南药资源产业化关键技术研究海口市重点实验室,海口571158 [3]中国科学院昆明动物研究所中国科学院动物模型与人类疾病机理重点实验室,昆明650223

出　　处：《有机化学》2018年第11期3137-3140,共4页Chinese Journal of Organic Chemistry

基　　金：海南省重点研发计划(No.ZDYF2016221);海口市重点研发计划(No.2017050);国家自然科学基金(Nos.21662011;31660097);教育部创新发展团队项目(No.IRT-16R19)资助项目~~

摘　　要：综合运用硅胶柱色谱、反相硅胶柱色谱、Sephadex LH-20凝胶柱色谱以及制备型高效液相色谱等色谱分离技术对大戟科三宝木属植物异叶三宝木Trigonostemon heterophyllus枝叶中的化学成分进行了系统研究,从其枝叶的85%乙醇提取物中分离得到了8个二萜类化合物.采用多种波谱鉴定技术确定了这些化合物的化学结构.其中一个化合物为新的罕见的stemodane型二萜类化合物,七个化合物为首次从三宝木属植物中分离得到的化合物.所有化合物的体外细胞毒活性评价结果表明,它们对五种肿瘤细胞株(HL-60、A549、SMMC-7721、MCF-7和SW480)均显示出了较为显著的体外生长抑制活性,它们的细胞毒活性与抗肿瘤阳性对照药顺铂的活性相当.A new stemodane diterpenoid,trigoheterone A (1),together with seven known diterpenoids,was isolated from the stems and leaves of Trigonostemon heterophyllus.Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from the genus Trigonostemon for the first time.The cytotoxicities of all isolated com- pounds were evaluated against five cancer cell lines (HL-60,A549,SMMC-7721,MCF-7and SW480).As a result,eight compounds exhibited significant inhibitory effects with IC50values comparable to those of cisplatin.

关 键 词：三宝木属 异叶三宝木 stemodane型二萜 细胞毒活性 

分 类 号：R284[医药卫生—中药学]