右美托咪定混合罗哌卡因用于上肢手术患者臂丛神经阻滞的有效性:meta分析  

Efficacy of dexmedetomidine mixed with ropivacaine for brachial plexus block in patients undergoing upper limb surgery:a meta-analysis

作　　者：朱娜娜 向导[1] 朱琳[1] 曹亚楠[1] 韩雪萍[1] 张卫[1] 孙振涛[1] Zhu Nana;Xiang Dao;Zhu Lin;Cao Yanan;Han Xueping;Zhang Wei;Sun Zhentao(Department of Anesthesiology,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院麻醉科,450000

出　　处：《中华麻醉学杂志》2018年第6期703-706,共4页Chinese Journal of Anesthesiology

摘　　要：目的采用meta分析评价右美托咪定混合罗哌卡因用于上肢手术患者臂丛神经阻滞的有效性。方法通过计算机检索Medline、PubMed、Embase、Web of Science、维普、万方、知网等数据库,检索时间为建库至2017年7月,语种为中文与英文。收集研究右美托咪定混合罗哌卡因用于上肢手术患者臂丛神经阻滞效果的随机对照试验。评价指标包括:感觉神经阻滞起效时间和持续时间、运动神经阻滞起效时间和持续时间、臂丛神经阻滞镇痛时间。由2名研究者独立地筛选研究并提取数据,采用RevMan 5.3软件对数据进行meta分析。结果共纳入12项随机对照研究,共815例患者。与对照组比较,右美托咪定组感觉神经阻滞和运动神经阻滞起效时间缩短,持续时间延长,臂丛神经阻滞镇痛时间延长(P<0.01)。结论右美托咪定混合罗哌卡因可有效地用于上肢手术患者臂丛神经阻滞。Objective To systematically review the efficacy of dexmedetomidine mixed with ropivaeaine for brachial plexus block in the patients undergoing upper limb surgery.Methods Medline, PubMed,Embase,Web of Science,Weipu,Wanfang,Zhiwang databases were searched for randomized controlled trials involving the efficacy of dexmedetomidine mixed with ropivaeaine for brachial plexus block in patients undergoing upper limb surgery from the date of database establishment up to July 2017,and the trials were published in Chinese or in English.Evaluation indexes included onset time and duration of sensory and motor blocks and analgesia time when used for brachial plexus block.Trials were selected and data were extracted independently by 2investigators,and meta-analysis was conducted using the Coehrane Collaboration's RevMan 5.3software.Results Twelve randomized controlled trials were included in our metaanalysis.Compared with control group,the onset time of sensory and motor blocks was significantly shortened,the duration of sensory and motor blocks was prolonged,and analgesia time when used for brachial plexus block was prolonged in dexmedetomidine group (P<0.01).Conclusion Dexmedetomidine mixed with ropivaeaine can be effectively used for brachial plexus block in the patients undergoing upper limb surgery.

关 键 词：右美托咪啶 酰胺类 臂丛 神经阻滞 META分析 

分 类 号：R614[医药卫生—麻醉学]