辐射相关microRNA研究进展  

Research progress on radiation-induced microRNA

作　　者：刘洋[1] 陈献文[1] 朱宝立[2] LIU Yang;CHEN Xian-wen;ZHU Bao-li(Institute of Public Health,Jiangyin Center for Disease Control and Prevention,Wuxi Jiangsu,214434;Institute of Occupational Disease Control and Prevention,Jiangsu Center for Disease Control and Prevention,Nanjing Jiangsu,210028,China)

机构地区：[1]江阴市疾病预防控制中心公共卫生所,江苏无锡214434 [2]江苏省疾病预防控制中心职业病防治所,江苏南京210028

出　　处：《职业与健康》2018年第23期3310-3312,共3页Occupation and Health

基　　金：江苏省医学创新团队项目(CXTDA2017029)

摘　　要：微小RNA(miRNA)是一类长度为21~25核苷酸(nt)的单链非编码小RNA分子,它们普遍存在于真核细胞内。大量研究发现,辐射可以诱导一系列miRNA分子的表达,辐射诱导的miRNA与辐射损伤及光损伤、辐射的敏感性、辐射诱导肿瘤的发生和辐射旁观者效应有着密切的关系。本文概述辐射诱导miRNA的研究进展,旨在为放射病的防护和肿瘤放疗提供新思路。MicroRNAs(miRNAs)are small single-stranded noncoding RNAs consisting of 21-25 nucleotides that are widespread in the eukaryotic cells. A lot of research found that the radiation may induce the expression of a series of miRNAs molecules , miRNAs have a close relationship with radiation damage or light damage,radiation sensitive,the occurrence of tumors induced by radiation and the bystander effect. The research progress on radiation-induced miRNAs is reviewed in this paper,and its target is to provide a new thinking for the protection of radiation sickness and radiotherapy of tumor.

关 键 词：微小RNA 辐射 放射病 基因表达 

分 类 号：R146[医药卫生—公共卫生与预防医学]