慢性阻塞性肺疾病合并呼吸衰竭及心力衰竭患者血清胆碱酯酶活性的变化  

The Alteration of Serum Cholinesterase Activity in COPD Patients with Respiratory Failure or Heart Failure

作　　者：董绍臣[1] 孙丽敏[1] 冯建双 乔华[1] 齐曦明[1] Dong Shaochen;Sun Limin;Feng Jianshuang;Qiao Hua;Qi Ximing(The First Hospital of Qinhuangdao,Qinhuangdao 066000,China)

机构地区：[1]河北省秦皇岛市第一医院

出　　处：《国际老年医学杂志》2018年第6期283-286,共4页International Journal of Geriatrics

基　　金：2016年秦皇岛市市级科技计划项目(201602A193)

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)、COPD伴呼吸衰竭及COPD伴心力衰竭患者之间的血清胆碱酯酶活性差异并分析其临床意义。方法回顾性分析我院2011~2014年住院的505例COPD患者的临床资料,分为单纯COPD组208例、COPD合并呼吸衰竭组115例及COPD合并心力衰竭组182例,比较血清胆碱酯酶在3组之间的差异。结果血清胆碱酯酶活性在单纯COPD组、COPD合并呼吸衰竭组及COPD合并心力衰竭组递次降低,差异具有统计学意义(P<0.05),尤其是COPD合并心力衰竭组血清胆碱酯酶活性较单纯COPD组和COPD合并呼吸衰竭组降低非常明显。结论血清胆碱酯酶活性对于临床区分单纯COPD、COPD合并呼吸衰竭和COPD合并心力衰竭进而提示对COPD合并心力衰竭患者进行早期干预治疗以减少死亡率具有临床意义。Objective To assess the alteration of serum cholinesterase activity in chronic obstructive pulmonary diseases (COPD)patients with respiratory failure or heart failure.Methods 505patients with COPD from 2011to 2014in our hospital were selected and the clinical data were retrospectively analyzed.Among them,there were 208cases without respiratory failure or heart failure,115cases with respiratory failure and 182cases with heart failure.Serum cholinesterase activity in these three groups of patients was compared.Results Serum cholinesterase activity in simple COPD patients,COPD patients with respiratory failure and COPD patients with heart failure was decreased successively.There were significant differences between three groups of patients (P < 0.05).Serum cholinesterase activity in COPD patients with heart failure was lower than those in simple COPD patients and in COPD patients with respiratory failure.Conclusion Serum cholinesterase activity could be used to distinguish simple COPD,COPD with respiratory failure and COPD with heart failure.

关 键 词：血清胆碱酯酶 慢性阻塞性肺疾病 心力衰竭 呼吸衰竭 

分 类 号：R563[医药卫生—呼吸系统] R541.6[医药卫生—内科学]