围术期去除白细胞的红细胞输注减轻输血对膀胱癌患者的免疫抑制  

Influence of perioperative leukodeplated red blood cell transfusion on immune function of patients with bladder cancer

作　　者：石洁[1] 高琲[2] 杨勇毅[3] 杨兰[1] 李晓娟[1] SHI Jie;GAO Bei;YANG Yongyi;YANG Lan;LI Xiaojuan(Department of Blood Transfusion of Second Hospital of Lanzhou University,Lanzhou 730030;Department of Pharmacy of Gansu Provincial Hospital,Lanzhou 730000;Blood Center of Gansu Province,Lanzhou 730046,China)

机构地区：[1]兰州大学第二医院输血科,甘肃兰州730030 [2]甘肃省人民医院药剂科,甘肃兰州730000 [3]甘肃省血液中心,甘肃兰州730046

出　　处：《细胞与分子免疫学杂志》2018年第7期632-636,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：甘肃省科技厅青年基金(145RJYA252).

摘　　要：目的观察去除白细胞的红细胞输血对膀胱癌患者免疫功能的影响。方法将48例围术期中拟行输血的膀胱癌患者随机分为两组:去除白细胞的红细胞输注组(Ⅰ组) 22例,普通悬浮红细胞输注组(Ⅱ组) 26例。对两组输血前后的T细胞亚群,自然杀伤(NK)细胞活性,红细胞C3b受体(RBC-C3bR)花环率及血清免疫抑制酸性蛋白(IAP)进行检测并作统计学处理。结果两组患者的免疫功能在输血前无明显差异,输血后两组患者的细胞免疫功能均下降,其中Ⅰ组患者的细胞免疫功能高于Ⅱ组,两组患者输血后IAP较输血前升高,其中Ⅰ组IAP低于Ⅱ组。结论围术期输血可使膀胱癌患者免疫功能下降,与悬浮红细胞相比,去除白细胞的红细胞输注可在一定程度上减轻输血对膀胱癌患者的免疫抑制。Objective To investigate the effect of leukodeplated red blood cell( RBC) transfusion on immune function of patients with bladder cancer. Methods A total of 48 patients with bladder cancer who required perioperative RBC transfusion were randomized into two groups: 22 received leukodeplated RBC transfusion( Group Ⅰ) and 26 received suspended RBC transfusion( Group Ⅱ). T-cell subgroup,natural killer cell activity,erythrocyte-C3 b receptor rosette formation rate,and immunosuppressive acidic protein( IAP) level were determined for the two groups before and after transfusion,and the results were statistically analyzed. Results There was no obvious difference in immune function between the two groups before transfusion. After transfusion,the immune function of both groups was lower. However,it was higher in Group I than in Group Ⅱ. IAP level was higher after transfusion than before transfusion; however,it was lower in GroupⅠthan in Group Ⅱ.Conclusion Perioperative RBC transfusion can decrease immune function in patients with bladder cancer. Compared with suspended RBC transfusion,leukodeplated RBC transfusion can improve immune function in patients with bladder cancer.

关 键 词：去除白细胞的红细胞 膀胱癌 输血 免疫 

分 类 号：R457.1[医药卫生—治疗学] R737.14[医药卫生—临床医学]