NLRP3炎症小体对肾脏疾病的作用研究进展  

Research Progress in the Role of NLRP3 Inflammasome in Renal Diseases

作　　者：陈林[1] 许欢 邢莎莎[3] 曾琦纹 杨亚飞[1] 刘俊莹 杨德华[2] Chen Lin;Xu Huan;Xing Shasha;Zeng Qiwen;Yang Yafei;Liu Junying;Yang Dehuac(Department of Urology Affiliated Hospital of Chengdu University,Chengdu 610081,China;2.Central Laboratory Affiliated Hospital of Chengdu University,Chengdu 610081,China;3.Drug Clinical Trial Center,Affiliated Hospital of Chengdu University,Chengdu 610081,China)

机构地区：[1]成都大学附属医院泌尿外科,成都610081 [2]成都大学附属医院中心试验室,成都610081 [3]成都大学附属医院药物临床实验中心,成都610081

出　　处：《中国药师》2018年第12期2218-2223,共6页China Pharmacist

摘　　要：NLRP3炎症小体是一种多蛋白复合体,在肾脏相关疾病中发挥致炎作用,本文旨在探讨NLRP3炎症小体在肾脏疾病中激活的机制及其在肾脏疾病发展中起到的作用,进一步清晰地认识到NLRP3炎症小体与肾脏疾病的联系,指导药物的开发和应用。NLRP3 inflammasome is a multi-protein complex that plays a role in the inflammation of kidney-related diseases.The article aimed to investigate the activation mechanism of NLRP3 inflammasome in kidney diseases and its role in the development of kidney diseases to further recognize the link between NLRP3 inflammasome and kidney diseases clearly,and guide the development and application of drugs.

关 键 词：肾脏疾病 NLRP3炎症小体 致炎作用 

分 类 号：R692[医药卫生—泌尿科学]