布洛芬肠溶滴丸在Beagle犬体内的药物动力学研究  

Pharmacokinetics of Ibuprofen Enteric Dropping Pills in Beagle Dogs

作　　者：郭咸希[1] 胡拥军[2] 喻海林 宋玲[2] Guo Xianxi;Hu Yongjun;Yu Hailin;Song Ling(Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Pharmacy,Maternal and Child Health Hospital;No.477Hospital of the PLA)

机构地区：[1]武汉大学人民医院药学部,武汉430060 [2]湖北省妇幼保健院药剂科 [3]解放军第477医院

出　　处：《中国药师》2018年第12期2260-2261,2265,共3页China Pharmacist

摘　　要：目的:考察布洛芬(IPF)肠溶滴丸单次给药在Beagle犬体内的药物动力学特性。方法:实验动物随机分为2组,每组各3只,分别给予同剂量的市售IPF片或IPF肠溶滴丸,在预定时间点取血样检测血浆中药浓,用DAS 2. 0软件进行模型拟合及药动学参数计算,并进行生物等效性评价。结果:市售IPF片、IPF肠溶滴丸在犬体内药动学均符合单室模型,与IPF片相比,IPF肠溶滴丸的C_(max),AUC_(0-∞)均有显著增加,T_(max)滞后,且差异均有统计学意义(P <0. 05),其相对生物利用度为(205. 89±4. 04)%。结论:与市售IPF片相比,IPF肠溶滴丸在犬体内达峰时间滞后,但达峰浓度及生物利用度显著增加,显示肠溶性及高效性。Objective: To study the pharmacokinetics of ibuprofen( IPF) enteric-coated dropping pills in Beagle dogs after single oral administration. Methods: Beagle dogs were randomly divided into two groups with 3 ones in each,and respectively given the marketed IPF tablets and IPF enteric-coated dropping pills with the same dosage. At the predetermined time points,the plasma IPF concentration was detected. DAS 2. 0 software was applied in the model fit and parameter calculation,and the bioequivalence was also evaluated. Results: Both the marketed IPF tablets and the enteric-coated dropping pills were fitted one-compartment models. Compared with those of IPF tablets,the Cmax and AUC0-∞of IPF enteric-coated dropping pills showed notable increase,and Tmax delayed significantly( P < 0. 05). The relative bioavailability of the dropping pills was(205. 89 ± 4. 04) %. Conclusion: Compared with the marketed IPF tablets,IPF enteric-coated dropping pills are with delayed Tmax and increased Cmax and AUC,suggesting notable enteric release and high efficacy.

关 键 词：布洛芬 肠溶滴丸 药物动力学 BEAGLE犬 

分 类 号：R969.1[医药卫生—药理学]