多潘立酮联合双歧杆菌四联活菌防治低体重早产儿喂养不耐受的临床观察  

Clinical observation of domperidone combined with viable bifidobacterium quadruple for prevention and treatment of feeding intolerance in low birth weight premature infants

作　　者：廖振宾 殷茜 朱溪[1] LIAO Zhen-bin;YIN Qian;ZHU Xi(Department of Neonatology,Guangzhou Military Region General Hospital 157Branch,Guangzhou510510,China)

机构地区：[1]广州军区总医院一五七分院新生儿科,510510

出　　处：《中国实用医药》2018年第34期112-113,共2页China Practical Medicine

摘　　要：目的观察多潘立酮联合双歧杆菌四联活菌防治低体重早产儿喂养不耐受的临床疗效。方法 106例诊断为喂养不耐受的低体重早产儿,采用随机数字表法分为观察组和对照组,各53例。对照组给予多潘立酮治疗,观察组给予多潘立酮联合双歧杆菌四联活菌治疗。比较两组治疗效果和临床观察指标。结果观察组总有效率为98.11%,明显高于对照组的77.36%,差异有统计学意义(P<0.05)。观察组喂养不耐受消失时间(2.71±0.31)d、达到完全经口喂养时间(11.68±3.15)d明显短于对照组的(3.39±0.37)、(17.57±4.09)d,每日增奶量(16.34±2.17)ml/kg、体重增加量(24.53±1.27)g/d明显多于对照组的(12.08±1.72)ml/kg、(21.07±0.97)g/d,差异有统计学意义(P<0.05)。结论采用多潘立酮联合双歧杆菌四联活菌防治低体重早产儿喂养不耐受的临床疗效极佳,喂养不耐受消失时间和达到完全经口喂养时间缩短,每日增奶量和体重增加量提高,值得在临床中广泛应用。Objective To observe the clinical efficacy of domperidone combined with viable bifidobacterium quadruple for prevention and treatment of feeding intolerance in low birth weight premature infants. Methods A total of 106 low birth weight premature infants diagnose as feeding intolerance were divided by random number table into observation group and control group, with 53 cases in each group. The control group was treated with domperidone, and the observation group was treated with viable bifidobacterium quadruple. The treatment effect and clinical observation indexes in two groups was compared. Results The observation group had obviously higher total effective rate as 98.11% than 77.36% in the control group, and the difference was statistically significant(P<0.05). The observation group had obviously shorter disappearance time of feeding intolerance as(2.71±0.31) d, complete oral feeding time as(11.68±3.15) d than(3.39±0.37) and(17.57±4.09) d in the control group, and obviously more daily milk increase as(16.34±2.17) ml/kg and weight gain as(24.53±1.27) g/d than(12.08±1.72) ml/kg and(21.07±0.97) g/d in the control group. Their difference was statistically significant(P<0.05). Conclusion Combination of domperidone and viable bifidobacterium quadruple shows excellent clinical effect in prevention and treatment of feeding intolerance in low birth weight premature infants, and it can shorten disappearance time of feeding intolerance and the complete oral feeding time, increase daily milk and body weight gain. So it is worthy of wide application in clinic.

关 键 词：多潘立酮 双歧杆菌四联活菌 低体重早产儿 喂养不耐受 

分 类 号：R722.6[医药卫生—儿科]