“循环通络”乳膏剂制备及其抗类风湿性关节炎的考察  

Preparation process and anti-rheumatoid arthritis investigation of XUN HUAN TONG LUO ointments

作　　者：尤钺 许灵善 郭建鹏[1,3] YOU Yue;XU Lingshan;GUO Jianpeng(College of Pharmacy,Yanbian University,Yanji 133002,China;Longjing Industrial Concentration District Management Committee,Longjing 133400,China;Key Laboratory of Natural Resources of Changbai Mountain &Function Molecules(Yanbian University),Ministry of Education,Yanji 133002,China)

机构地区：[1]延边大学药学院,吉林延吉133002 [2]龙井工业集中区管理委员会,吉林龙井133400 [3]长白山生物资源与功能分子教育部重点实验室(延边大学),吉林延吉133002

出　　处：《延边大学学报（自然科学版）》2018年第3期250-255,共6页Journal of Yanbian University（Natural Science Edition）

基　　金：延边朝鲜族自治州科技发展计划项目(2014AC17)

摘　　要：以综合评分为指标,通过正交设计试验优选"循环通络"乳膏剂处方,并采用单因素试验对其制备工艺参数进行了优化.研究表明,乳膏剂的最佳处方为浓缩药液200g、凡士林90g、羊毛脂10g、液体石蜡80g、单硬脂酸甘油酯50g、硬脂酸65g、丙三醇150g、吐温80 40g、月桂氮酮10g、尼泊金乙酯0.5g,用水加至1 000g.制备的最佳工艺为油、水相分别加入乳化,搅拌速度为250r·min-1,乳化温度为70℃,乳化时间为15min.抗类风湿性关节炎实验结果表明,该乳膏能够改善大鼠的关节肿胀,降低大鼠血清中炎症因子(TNF-α,IL-1β,IL-6)的含量和增加抗炎细胞因子IL-10的含量.Based on the comprehensive score as the index,the ortho gonal desi gn experiment was used to select the prescription of XUN HUAN TON g LUO ointments,and the sin gle factor experimental method was used to optimize the process parameters.The optimum prescription of ointments is finally obtained as a concentrated liquid 200 g,petrolatum 90 g,lanolin 10 g,liquid paraffin 80 g, glyceryl monostearate 50 g,stearic acid 65 g, glycerol 150 g,Tween-8040 g,laurocapram 10 g,ethylparaben 0.5 g,and add water to 1000 g.The optimum process implied that emulsification is.attributed to add two phases of oil and water respectively,the stirrin g speed of 250r·min^-1,the emulsification temperature of 70℃ and the emulsification time of 15min. Anti-rheumatoid arthritis experiments showed that the ointments can improve joint swellin g in rats,reduce the levels of inflammatory factors (TNF-α,IL-1βand IL-6)in the serum of rats,increase the content of anti-inflammatory factor (IL-10).

关 键 词：类风湿性关节炎 朝药复方 正交设计 综合评分 

分 类 号：R944.9[医药卫生—药剂学]