MRI m—Dixon—Quant技术快速评估中老年骨质疏松症的可行性研究  

The feasibility study of MRI m-Dixon-Quant technique to rapidly evaluate middle-aged and elderly osteoporosis

作　　者：常荣 张红[1] 刘正华[1] 尚潘 孔江涛 马晓文[1] CHANG Rong;ZHANG Hong;LIU Zhenghua;SHANG Pan;KONG J iangtao;MA Xiaowen(Department of Radiology,Honghui Hospital ,Xi'an Jiaotong University ,Xi'an710054,China)

机构地区：[1]西安交通大学附属红会医院影像科,陕西西安710054

出　　处：《实用放射学杂志》2018年第12期1908-1911,1944,共5页Journal of Practical Radiology

摘　　要：目的基于MRI m-Dixon-Quant技术快速量化中老年人椎体骨髓脂肪含量,为骨质疏松症(OP)的诊断提供科学的依据。方法收集从2016年7月至2017年7月在本院就诊的中老年人74例,收集患者的年龄、性别和体质量指数(BMI)等指标,所有研究对象均进行骨密度(BMD)、脂肪分数(FF)等指标的测量。根据美国放射学院(ACR)关于骨密度测量指南,通过骨密度值对研究对象分类,采用受试者工作特征曲线(ROC曲线)对FF进行诊断分析。结果研究对象平均年龄为(59.50±8.72)岁,MRI m-Dixon-Quant FF与年龄存在正相关关系(r=O.436),与骨密度平均值存在高度负相关关系(r=0.739)。通过ROC曲线分析发现正常组与低骨量组,灵敏度为74.2%,特异度为83.3%;正常组与OP组,灵敏度为92.0%,特异度为88.9%;低骨量组与OP组,灵敏度为72.0%,特异度87.1%。FF可以用于OP的评估,若FF^54.60,则认为骨量正常,若54.60≤FF≤65.20为低骨量,若FF>65.20则认为存在OP。结论MRI m-Dixon-Quant FF指标可以快速定量地用于0P的诊断,并且为0P的诊断提供一个新的参考指标。Objective Based on MRI m-Dixon-Quant technique to quickly quantify bone marrow fat content in the vertebral body of middle-aged and elderly patients,and provide a scientific basis for the diagnosis of osteoporosis(OP).Methods A total of 74middle-aged and elderly patients who were admitted to our hospital from July 2016to July 2017were collected.The age,sex and body mass index (BMI)of the patients were collected.All subjects were evaluated for bone mineral density (BMD)and fat fraction (FF)and other indicators of measurement.According to the guidelines for bone mineral density measurement by the American College of Radiology(ACR),the subject was classified by the bone mineral density value,and receiver operating characteristic(ROC)curve was used for the diagnosis and analysis of FF.Resnlts The average age of the subjects was (59.50-1-8.72)years.There was a positive correlation between MRI m-Dixon-Quant FF and age(r =0.436},which was highly negatively correlated with the average bone density{r =-0.739}.By ROC analysis,the sensitivity and specificity were 74.2%and 83.3%for normal and low bone mass groups,92.0%and 88.9%for the normal and OP groups,and 72.0%and 87.1%for the low bone mass and OP groups.FF could be used for the evaluation of OP.If FF<54.60,normal bone mass was considered.If 54.60≤FF≤65.20,1ow bone mass was considered,if FF>65.20,OP was considered.Conclusion The MRI m-Dixon-Quant FF index can be rapidly and quantitatively used for the diagnosis of OP,which provides a new reference for the diagnosis of OP.

关 键 词：MRI m-Dixon-Quant 骨质疏松症 

分 类 号：R445.2[医药卫生—影像医学与核医学] R681[医药卫生—诊断学]