武汉市PLWHA抗病毒治疗服药依从性及相关因素  

Study on adherence to antiretroviral therapy and its associated factors among people living with HIV/AIDS in Wuhan City

作　　者：丁昌棉 杨银梅 王威 李十月 燕虹 DING Chang-mian;YANG Yin-mei;WANG Wei;LI Shi-yue;YAN Hong(Department of Epidemiology and Health Statistics,School of Health Science of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学健康学院流行病与卫生统计系

出　　处：《中华疾病控制杂志》2018年第12期1234-1237,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81673196);教育部人文社会科学研究规划基金(15YJAZH094);高等学校博士学科点专项科研基金(20130141110033)

摘　　要：目的 了解武汉市人免疫缺陷病毒(human immunodeficiency virus,HIV)感染者和获得性免疫缺陷综合征(acquired immune deficiency syndrome,AIDS)患者(people living with HIV/AIDS,PLWHA)抗病毒治疗服药依从性现状,分析其相关因素,为相关政策的制定提供参考依据。方法 采用方便抽样的方法,用自行设计的问卷进行面对面匿名调查。结果 在调查的451名PLWHA中,服药依从性均数为98. 73%,其中,有414人(91. 8%)服药依从性≥95%,37人(8. 2%)服药依从性<95%。多因素分析显示,治疗时间> 24月(OR=0. 383,95%CI:0. 191~0. 767,P=0. 007),歧视感知高(OR=0. 980,95%CI:0. 961~0. 999,P=0. 042)的PLWHA服药依从性越差。结论 武汉市PLWHA服药依从性较高,应加大对治疗时间较长,歧视感知水平较高的人群的关注,探索干预性措施,以提高患者的服药依从性。Objective To study adherence to antiretroviral therapy and its associated factors among people living with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) (PLWHA) in Wuhan City,so as to provide scientific evidence for policy making. Methods A face-to-face anonymous survey was conducted using self-designed questionnaire among PLWHA recruited by convenient sampling. Results Among 451 PLWHA,the average adherence was 98. 73%. 414(91. 8%) of respondents had 95% or higher adherence,while 37(8. 2%) had adherence less than 95%. Multivariate analysis showed that those PLWHA with more than 24 months’treatment duration (OR = 0. 383,95% CI:0. 191-0. 767,P =0. 007),higher stigma scale score (OR =0. 980,95% CI:0. 961-0. 999,P =0. 042) had worse adherence. Conclusions PLWHA in Wuhan City have high adherence to antiretroviral therapy. We should pay more attention on the people with longer treatment time and higher stigma score and explore intervention measures to improve patients'medication adherence.

关 键 词：人免疫缺陷病毒 获得性免疫缺陷综合征患者 抗病毒治疗 服药依从性 相关因素 

分 类 号：R512.91[医药卫生—内科学] R181[医药卫生—临床医学]