德宏州HIV单阳夫妻双方丙型肝炎病毒感染状况及影响因素  

Prevalence and correlates of HCV infection among HIV serodisordant couples in Dehong prefecture of Yunnan province

作　　者：王继宝[1] 徐晴晴 王译葵 段星[1] 杨锦[1] 曹艳芬[1] 杨涛[1] 叶润华[1] 杨跃诚[1] 姚仕堂[1] 丁盈盈 何纳 段松[1] WANG Ji-bao;XU Qing-qing;WANG Yi-kui;DUAN Xing;YANG Jin;CAO Yan-fen;YANG tao;YE Run-hua;YANG Yue-cheng;YAO Shi-tang;DING Ying-ying;HE Na;DUAN Song(Department of STD and AIDS Prevention and Control,Dehong Prefecture Center for Disease Control and Prevention,Dehong prefecture 678400,China;National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Department of Epidemiology,School of Public Health,Fudan University,Shanghai 200032,China)

机构地区：[1]德宏州疾病预防控制中心艾滋病性病防制科,云南德宏州678400 [2]中国疾病预防控制中心性病艾滋病预防控制中心,北京102206 [3]复旦大学公共卫生学院流行病学教研室,上海200032

出　　处：《中华疾病控制杂志》2018年第12期1283-1286,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家重点地区艾滋病防治项目国家科技重大专项(2013zx10004-906)

摘　　要：目的 了解云南省德宏州人类免疫缺陷病毒(human immunodeficiency virus,HIV)单阳夫妻双方(HIV感染者及其阴性配偶)丙型肝炎病毒(viral hepatitis C,HCV)感染情况及其影响因素。方法 收集HIV单阳夫妻的人口学特征、行为学指标和血样,并进行HCV抗体检测,应用χ^2检验和Logistic回归分析不同因素对HCV感染率的影响。结果 582对HIV单阳家庭中,夫妻双方均感染HCV有12对(2. 1%),仅一方感染HCV有138对(23. 7%)。HIV阳性配偶HCV感染率为23. 2%,HIV阴性配偶HCV感染率为4. 6%,差异有统计学意义(χ^2=83. 641,P <0. 001)。男性配偶中,HIV阳性者HCV感染率为32. 6%,HIV阴性者HCV感染率为4. 6%,差异有统计学意义(χ^2=56. 828,P <0. 001);女性配偶中,HIV阳性者HCV感染率为4. 6%,HIV阴性者HCV感染率为4. 7%,二者无统计学差异(χ^2<0. 001,P=0. 958)。多因素Logistic回归分析显示,男性配偶中35~46岁、景颇族、HIV阳性、吸毒是HCV感染的危险因素。结论 德宏州HIV单阳夫妻特别是HIV阳性男性配偶中HCV感染率高,HCV存在性传播的潜在威胁,有必要加强对HIV单阳家庭的丙型肝炎防治,对男性和女性配偶采取针对性的预防干预措施。Objective To examine the prevalence and correlates of HCV infection among HIV serodisordant cou- ples in Dehong prefecture,Yunnan province. Methods A cross-sectional questionnaire interview was administered to so- licit sociodemographic and behavioral characteristics of HIV serodiscordant couples. Blood was collected for HCV antibody testing using commercial Anti-HCV EIA Kit. Results Among 582 HIV serodiscordant couples,12 (2. 1%) couples were concordantly HCV positive,and 138 (23. 7%) were HCV-discordant. The HCV prevalence was 23. 2% for HIV-positive spouses,significantly higher than that (4. 6%) for HIV-negative spouses (χ^2 = 83. 641,P<0. 001). The HCV preva- lence was 32. 6% for HIV-positive male spouses,significantly higher than that (4. 6%) for HIV-negative male spouses (χ^2 =56. 828,P<0. 001). No significant difference in HCV prevalence was found between HIV-positive (4. 6%) and HIV-negative female spouses (4. 7%) (χ^2 <0. 001,P =0. 958). Multivariable Logistic regression analysis indicated that HCV infection was positively associated with age at 35 -46,Jingpo minority,HIV infection and drug use. Conclusions HCV prevalence was high among HIV-serodiscordant couples especially HIV-infected male spouses. There was a potential sexual transmission of HCV. These findings underscore the importance of enhancing tailored HCV prevention and control among these people.

关 键 词：HIV HCV 单阳家庭 影响因素 

分 类 号：R512.91[医药卫生—内科学] R512.63[医药卫生—临床医学]