桑白利湿汤治疗感染后咳嗽的疗效和对诱导痰中P物质、降钙素基因相关肽水平的影响  

Effects of Sangbailishi decoction on post infection cough( lung heat damp syndrome) and the level of substance P and calcitonin gene related peptide in induced sputum

作　　者：李献超[1] 马晓东[1] 郑青秀[1] 刘刚[1] LI Xianchao;MA Xiaodong;ZHENG Qingxiu;LIU Gang(Department of Respiratory Medicine,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou 325000,Zhejiang,China)

机构地区：[1]浙江温州市中医院呼吸内科

出　　处：《中国临床药理学与治疗学》2018年第11期1282-1286,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省中医药科学研究项目(2015ZA196)

摘　　要：目的:探讨桑白利湿汤治疗感染后咳嗽(肺热夹湿证)的疗效和对诱导痰中P物质(SP)、降钙素基因相关肽(CGRP)水平的影响。方法:将60例感染后咳嗽(肺热夹湿证)患者分为治疗组和对照组。对照组采用美敏伪麻治疗。治疗组采用桑白利湿汤治疗。记录两组的咳嗽缓解时间、咳嗽复发次数。采用咳嗽症状积分评估患者的咳嗽程度;采用证候疗效计分评估患者的病情变化;采用视觉模仿评分(VAS)评估咳嗽病情变化。检测两组治疗前后诱导痰SP、CGRP的水平。结果:治疗组的总有效率比对照组高(P <0. 05);治疗组的咳嗽缓解时间、咳嗽复发次数比对照组低(P <0. 05);两组治疗后日间咳嗽积分、夜间咳嗽积分、VAS评分、证候疗效计分降低(P <0. 05),且治疗组低于对照组(P <0. 05);两组治疗后的SP、CGRP显著降低(P <0. 05),且治疗组的SP、CGRP低于对照组,差异有统计学意义(P<0. 05)。结论:桑白利湿汤治疗感染后咳嗽(肺热夹湿证)的疗效确切,能显著降低诱导痰SP、CGRP的水平。AIM: To explore Sangbailishi decoction in the treatment of post infection cough (lung heat damp syndrome) and the effect on the level of substance P (SP) and calcitonin gene related peptide (CGRP) in induced sputum. METHODS: Sixty patients with post infection cough (lung heat damp syndrome) were divided into the treatment group and the control group. The control group received dextromethorphan chlorpheniramine pseudoephedrine. The treatment group was treated with Sangbailishi decoction. The time of cough remission and the frequency of coughing recurrence were recorded and compared between two groups. Cough symptom score was used to evaluate the change of patients' cough symptoms. The severity of coughing was assessed by visual imitative score (VAS). The symptoms of the patients were evaluated by the score of the syndrome. The levels of SP and CGRP were detected and compared betweeen the two groups before and after treatment. RESULTS:The total effective rate of the treatment group was higher than that of the control group (P<0.05). The time of cough remission and the number of coughing recurrences in the treatment group were lower than those in the control group (P<0.05). After treatment, The score of day cough score, night cough score, VAS score and syndrome effect score of the two groups were significantly reduced (P<0.05), and those of the treatment group were lower than those in the control group (P<0.05). After treatment, SP and CGRP were significantly decreased (P<0.05) and those of the treatment group were lower than those in the control group (P<0.05). CONCLUSION: Sangbailishi decoction is effective in the treatment of post infection coughing (lung heat damp syndrome), and can significantly reduce the level of SP and CGRP in induced sputum.

关 键 词：桑白利湿汤 感染后咳嗽 P物质 降钙素基因相关肽 

分 类 号：R256.11[医药卫生—中医内科学] R56[医药卫生—中医学]