宫腔内注射hCG在子宫内膜异位症患者冻融胚胎移植周期中的应用与效果  

Application and effect of intrauterine injection of human chorionic gonadotropin in frozen-thawed embryo transfer cycle for endometriosis patients

作　　者：徐芝慧[1] 周洁春 陈惠南[1] 王安兰 XU Zhihui;ZHOU Jiechun;CHEN Huinan;WANG Anlan(Department of Reproductive Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州医科大学附属第一医院生殖医学中心

出　　处：《中国临床药理学与治疗学》2018年第11期1287-1291,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：温州市科技局公益性科技计划项目(Y20170593)

摘　　要：目的:探讨冻融胚胎移植前行宫腔内注射人绒毛促性腺激素(h CG)对子宫内膜异位症患者冻融胚胎移植周期妊娠结局的影响。方法:回顾性分析子宫内膜异位症患者冻融胚胎移植周期228个,按照宫腔内是否注射h CG分为宫腔内注组(50个周期)和无宫腔内注射的对照组(178个周期)。比较两组年龄、不孕年限、体质量指数、激素水平、内膜厚度、胚胎质量,以及临床妊娠率、活产率,分析子宫内膜异位症冻融胚胎移植周期活产的相关影响因素。结果:两组患者年龄等基本特征以及激素、内膜厚度、胚胎质量等方面均无统计学差异(P> 0. 05),但宫腔内注组活产率高于对照组(P <0. 05),且流产率低于对照组(P <0. 05)。年龄和宫腔内注射hCG是活产的独立影响因素。结论:子宫内膜异位症患者冻融胚胎移植前行宫腔内注射hCG有利于提高此类患者冻融胚胎移植后的活产率,降低流产率。AIM: To investigate the effect of intrauterine injection of human chorionic gonadotropin (hCG) upon pregnancy outcomes following frozen-thawed embryo transfer (FET) for endometriosis (EMs) patients. METHODS: We retrospectively collected 228 FET cycles of EMs patients, and divided them into intrauterine injection group (50 cycles) and control group (178 cycles). Age, infertile duration, body mass index, hormone profile, endometrial thickness, embryo quality, clinical pregnancy rate and live birth rate were compared, the related factors affecting live birth were further analyzed. RESULTS: No significant difference was detected when baseline character, hormone change, endometrial thickness and embryo quality were compared between two groups, while live birth rate was found statistically higher and miscarriage rate was remarkably lower in intrauterine injection group. Age and intrauterine injection of hCG were two independent factors affecting live birth in EMs following FET. CONCLUSION: Intrauterine injection of hCG prior to FET can improve the live birth rate and reduce the miscarriage rate for EMs patients.

关 键 词：子宫内膜异位症 冻融胚胎移植 宫腔注射 绒毛膜促性腺激素 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学] R711.71[医药卫生—基础医学]