抗HPV生物蛋白敷料阴道上药治疗HPV高危感染并CINⅠ的效果观察  

Observation on the Effect of Vaginal Administration of Anti-HPV Biological Protein Dressing in the Treatment of HPV High-Risk Infection Complicated with CINⅠ

作　　者：张燕珠[1] 王洁梅 陈秀婷[1] ZHANG Yanzhu;WANG Jiemei;CHEN Xiuting(Department of Gynecology,Huizhou Third People's Hospital,Huizhou 516002,China)

机构地区：[1]惠州市第三人民医院妇科,广东惠州516002

出　　处：《临床医学工程》2018年第12期1647-1648,共2页Clinical Medicine & Engineering

摘　　要：目的观察抗人乳头瘤病毒(HPV)生物蛋白敷料阴道上药治疗HPV高危感染并宫颈上皮内瘤变(CIN)Ⅰ的效果。方法 148例HPV高危感染并宫颈CINⅠ患者,按就诊顺序分为实验组(81例)和对照组(67例)。实验组行抗HPV生物蛋白敷料阴道上药治疗,对照组未使用药物。比较两组干预后第4个月的HPV检测和宫颈脱落细胞学检查结果。结果实验组清除HPV感染的总有效率为80.25%,显著高于对照组的46.27%(P <0.05)。实验组HPV合并宫颈细胞学ASCUS/LSIL患者的转阴率为80.00%,显著高于对照组的33.33%(P <0.05)。结论抗HPV生物蛋白敷料阴道上药治疗HPV高危感染并CINⅠ患者有利于HPV的清除,还可提高宫颈脱落细胞学ASCUS/LSIL的转阴率。Objective To observe the effect of vaginal administration of anti-human papillomavirus (HPV)biological protein dressing in the treatment of I-IPV high-risk infection complicated with cervical intraepithelial neoplasia (CIN)I.Methods 148cases of patients with HPV high-risk infection complicated with CIN I were divided into two groups according to the treatment order.81cases of the experimental group were treated with vaginal administration of anti-HPV biological protein dressing,while 67cases of the control group did not use drug treatment.4months after intervention,the results of HPV test and cervical exfoliated cytology test were compared between the two groups. Results The total effective rate of removal of HPV infection in the experimental group was 80.25%,significantly higher than 46.27%in the control group (P <0.05).The negative conversion rate of patients with HPV complicated with cervical cytology ASCUS/LSIL in the experimental group was 80.00%,significantly higher than 33.33%in the control group (P<0.05).Conclusions The vaginal administration of anti-HPV biological protein dressing in the treatment of patients with HPV high-risk infection complicated with CIN I helps to improve the HPV clearance,and improve the negative conversion rate of cervical cytology ASCUS/LSIL.

关 键 词：HPV高危感染 CINⅠ 抗HPV生物蛋白敷料 

分 类 号：R711.74[医药卫生—妇产科学]