肠道菌群与大脑功能相互联系的研究进展  

Recent advance in interaction between intestinal flora and brain function

作　　者：王姣姣 张瑞光 董晓荣 Wang Jiaojiao;Zhang Ruiguang;Dong Xiaorong(Cancer Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院肿瘤中心,武汉430022

出　　处：《中华神经医学杂志》2018年第12期1281-1286,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(81172595,81573090,81773233).

摘　　要：定植于人体肠道中的菌群在调节肠道功能与维持肠道稳态等生命活动中发挥着重要作用。近年来大量的基础研究提示肠道菌群可以通过肠-脑轴(GBA)与大脑进行双向交流。GBA是指肠道与大脑进行双向互动的神经体液网络,整合了免疫、迷走神经、内分泌、神经递质等多项元素。此外,越来越多的研究结果表明肠道菌群的失调或缺失可以导致多发性硬化症、阿尔茨海默病、帕金森病、自闭症谱系障碍以及肝性脑病等中枢神经系统疾病。本文围绕肠道菌群与大脑功能相互联系的研究进展展开综述,以期为肠道菌群与大脑之间的研究以及相关中枢神经系统疾病的治疗策略提供理论支持。The intestinal flora in the human intestinal tract plays an important role in regulating the intestinal function and maintaining the homeostasis of intestinal state.An increasing number of basic experimental studies have found that intestinal flora can communicate with brain through gut-brain axis (GBA).GBA refers to the neurohumoral network of two-way communication between the intestinal tract and the brain,including immunity,vagus nerve,endocrine,and neurotransmitter.In addition,a large number of studies have suggested that the disorder or absence of intestinal flora may lead to many central nervous system diseases,such as multiple sclerosis,Alzheimer's disease,Parkinson's disease,autism spectrum disorder,and hepatic encephalopathy.This article reviews the research progress of the interaction between intestinal flora and brain function to provide theoretical support for further researches on intestinal flora and brain,as well as the treatment strategies of related central nervous system diseases.

关 键 词：肠道菌群 肠-脑轴 大脑 中枢神经系统 

分 类 号：R378[医药卫生—病原生物学]