系统性红斑狼疮合并器官特异性自身免疫性疾病的相关研究进展  

Research progress on systemic lupus erythematosus overlapping organ-specific autoimmune diseases

作　　者：王星星 王盼盼 杨旭燕[1] WANG Xingxing;WANG Panpan;YANG Xuyan(Department of Rheumatism and Immunology,the Second Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou 310009,China;Department of Endocrinology,Chengdu University of TCM,Chengdu 610075,China)

机构地区：[1]浙江大学医学院附属第二医院风湿免疫科,浙江杭州310009 [2]成都中医药大学附属医院内分泌科,四川成都610075

出　　处：《浙江大学学报（医学版）》2018年第4期435-440,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省自然科学基金(Y15H1000006);国家自然科学基金(81571578)

摘　　要：系统性红斑狼疮(SLE)是一种多器官多系统累及的自身免疫性疾病,可以与器官特异性自身免疫性疾病如自身免疫性甲状腺疾病、自身免疫性肝炎、炎性肠疾病同时存在。SLE与这三种器官特异性自身免疫性疾病可能存在某种关联性,如相似的免疫学及基因背景,但其机制尚不清楚。本文就SLE合并上述三种自身免疫性疾病的可能机制、发病率和临床特征等作一综述。Systemic lupus erythematosus ( SLE ) is a multiorgan-involved autoimmune disease,and it can overlap organ-specific autoimmune diseases such as autoimmune thyroid diseases,autoimmune hepatitis and inflammatory bowel disease. There may be some association between SLE and these autoimmune diseases,such as common immunological and genetic basis,but the pathogenic mechanism is still unclear. This review focuses on current knowledge regarding the prevalence and possible pathogenesis of SLE overlapping the above three autoimmune diseases.

关 键 词：红斑狼疮 系统性 甲状腺炎 自身免疫性 肝炎 自身免疫性 结肠炎 溃疡性 克罗恩病 综述 

分 类 号：R593.241[医药卫生—内科学]