^18F-FDG PET/CT在IgG4相关性疾病中的临床应用  

Application of ^18F-FDG PET/CT in IgG4-related disease

作　　者：张洁[1] 兰晓莉[1] Zhang Jie;Lan Xiaoli(Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology、Hubei Key Laboratory of Molecular Imaging,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科、分子影像湖北省重点实验室,武汉430022

出　　处：《中华核医学与分子影像杂志》2018年第12期824-828,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：免疫球蛋白(Ig)G4相关性疾病(IgG4-RD)是近年来新确定的一种多器官受累的免疫性疾病,其特征为血清IgG4浓度升高、IgG4阳性淋巴浆细胞浸润。早期而全面的诊断有助于该病的治疗及预后改善。影像学可为IgG4-RD提供重要的诊断依据,但常规的影像学检查方法难以确定患者全身受累情况。^18F-脱氧葡萄糖(FDG)PET/CT可以显示全身受累器官的形态及代谢改变,可用于IgG4-RD的诊断、活组织检查指导、疗效评价及复发监测等各个方面,笔者就PET/CT在IgG4-RD的各个方面的应用及研究现况加以综述。Immunoglobulin (Ig)G4-related disease (IgG4-RD) is a new multi-organ immune-mediated disease, which was characterized by multiple organs involvement, high serum IgG4 concentrations and IgG4+ plasma cells infiltration. Early diagnosis is helpful for the treatment and prognosis evaluation. Imaging can provide important diagnostic bases for IgG4-RD, but conventional imaging methods are difficult to determine the overall involvement of the patient. ^18F-fluorodeoxyglucose (FDG) PET/CT can display the changes of morphology and metabolism in involved organs, and can be used in the diagnosis, guidance of biopsy, therapeutic response monitoring and recurrence of IgG4-RD. This review summarizes the applications of ^18F-FDG PET/CT in patients with IgG4-RD.

关 键 词：自身免疫疾病 免疫球蛋白G 正电子发射断层显像术 体层摄影术 X线计算机 脱氧葡萄糖 发展趋势 

分 类 号：R593.2[医药卫生—内科学] R817.4[医药卫生—临床医学]