低共熔溶剂氯化胆碱-尿素催化合成阿司匹林  

SYNTHESIS OF ASPIRIN CATALYZED BY DEEP EUTECTIC SOLVENT OF CHOLINE CHLORIDE-UREA

作　　者：王英磊[1,2] 陈鑫 常双强 李想 刘学国 张群安[1,2] Wang Yinglei;Chen Xin;Chang Shuangqiang;Li Xiang;Liu Xueguo;Zhang Qun'an(School of Biological and Chemical Engineering,Nanyang Institute of Technology,Nanyang 473004,He'nan,China;He'nan Key Laboratory of Industrial Microbial Resources and Fermentation Technology,Nanyang 473004,He'nan,China)

机构地区：[1]南阳理工学院生物与化学工程学院,河南南阳473004 [2]河南省工业微生物资源与发酵技术重点实验室,河南南阳473004

出　　处：《精细石油化工》2018年第6期72-75,共4页Speciality Petrochemicals

基　　金：河南省科技攻关项目(182102310601);河南省高等学校重点科研项目(17B150007)

摘　　要：以水杨酸和乙酸酐作为原料,采用低共熔溶剂氯化胆碱-尿素作为反应介质和催化剂,考察不同反应条件对阿司匹林合成的影响。实验结果表明,在反应温度80℃、酸酐摩尔比1∶2.5、反应时间40min、氯化胆碱-尿素用量1.5g时,阿司匹林的收率达94%。The influence of different reaction conditions on the synthesis of aspirin was investigated, by using salicylic acid and acetic anhydride as raw materials,and the deep eutectic solvent of choline chloride-urea as reaction medium and catalyst.The experimental results show that the yield of aspirin could reach 94%,using 80℃ of reaction temperature,1:2.5of molar ratio of salicylic acid to acetic anhydride,40min of reaction time,1.5 g of choline chloride-urea dosage.

关 键 词：低共熔溶剂 阿司匹林 绿色合成 循环使用 

分 类 号：TQ4634[化学工程—制药化工]