表面增强拉曼散射在外源性有害物质检测中应用研究进展  

Application Progress on Surface-enhanced Raman Scattering for Detection of Exogenous Hazardous Substances

作　　者：赵海艳 豆小文[1] 骆骄阳[1] 奚广生 杨美华[1] ZHAO Hai-yan;D0U Xiao-wen;LUO Jiao-yang;XI Guang-sheng;YANG Mei-hua(Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100193;College of Traditional Chinese Medicine ,Jilin Agricultural University ,Changchun 130118;College of Traditional Chinese Medicine ,J ilin Agricultural Science and Technology University ,Jilin 132109)

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,中草药物质基础与资源利用教育部重点实验室,北京100193 [2]吉林农业大学中药材学院,吉林长春130118 [3]吉林农业科技学院中药学院,吉林吉林132109

出　　处：《分析科学学报》2018年第6期829-833,共5页Journal of Analytical Science

基　　金：国家自然科学基金(No.81573595,81703699);国家中药标准化项目(No.ZYBZH-Y-JIN-34);中国医学科学院医学与健康科技创新工程(No.2017-I2M-1-013);中国医学科学院医学与健康科技创新工程(No.2016-12M-1-012).

摘　　要：表面增强拉曼散射(Surface Enhanced Raman Scattering,SERS)通过增强基底能灵敏探测化合物的分子指纹信息,从而清楚解析其特征化学结构。SERS用于复杂体系中特定微量成分的检测具有无损、无需分离处理、经济环保等独特的优势而受到广泛关注,该方法尤其适宜于环境、食品、药品安全领域中外源性有毒有害物质的筛检。本文系统综述SERS研究进展,包括增强机理、常用及新型基底,同时针对其在外源性有害物质检测实例中探讨了SERS的应用前景。基于此,展望SERS技术在外源性有害物质筛检中面临的机遇和挑战,旨在为实现该技术准确、灵敏、定量的快速检测发展提供参考。Surface enhanced raman scattering(SERS)can be used to detect the molecular fingerprint information of the compounds by substrate enhancement and detailed interpretation of its characteristic chemical structure.SERS has been paid much attention in the detection of specific elements at trace level in complex systems,because the technique possesses outstanding advantages including nondestructive testing,sample pretreatment without pre-separation,low cost and environmental protection.Therefore,it is suitable for screening of exogenous toxic and hazardous substances in the fields of environment,food and medicine safety.Herein,the progress and development of SERS research are systematically summarized including enhanced mechanism,common and new substrate.And the prospect of SERS is discussed based on various detection applications.Aiming at providing a reference for rapid,accurate,sensitive and quantitative techniques,we look forward to the opportunities and challenges of SERS technology in the exogenous hazardous substances screening and detecting.

关 键 词：表面增强拉曼散射 外源性有害物质 快速筛检 痕量分析 

分 类 号：O657.37[理学—分析化学]