天津地区儿童空腹与非空腹血脂水平比较  

Comparison of fasting and non -fasting blood lipid levels in children in Tianjin

作　　者：刘双庆[1] 宁莉[1] 武大伟[1] 王玉亮 Liu Shuangqing;Ning Li;Wu Dawei;Wang Yuliang(Department of Clinical Laboratory,the Second Hospital of Tianfin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院检验科,300211

出　　处：《中华实用儿科临床杂志》2018年第23期1803-1806,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：目的比较天津地区儿童空腹血脂与非空腹血脂的差异,探讨在儿童人群中进行非空腹血脂检测的可行性。方法选取2017年1月至2018年2月天津医科大学第二医院儿科住院患儿223例,分别采集空腹和餐后1~6h血液样本,进行总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL—C)和低密度脂蛋白胆固醇(LDL-C)检测,采用自身对照的方法进行比较,统计分析采用非参数检验Wilcoxon符号秩检验。结果与空腹血脂比较,非空腹TC升高0.02mmol/L,TG升高0.01mmol/L,HDL—C升高0.03mmol/L,LDL-C降低0.01mmol/L,非高密度脂蛋白胆固醇无变化。其中仅HDL—C非空腹检测与空腹检测差异有统计学意义(Z=-2.870,P<0.05),所有指标的差异变化率<3%。按照血脂异常分组比较结果显示,高TC血症(0.72mmol/L,Z=-2.551,P=0.011)、高TG血症(0.73mmol/L,Z=-3.846,P<0.001)、低HDL—C血症(-0.04mmoL/L,Z=-8.625,P<0.001)和正常水平HDL—C(0.1mmol/L,Z=-5.402,P<0.001),非空腹血脂与空腹血脂差异有统计学意义。结论天津地区儿童血脂谱在空腹与非空腹状态下检测改变较小,在儿童中进行血脂检测不必禁食,可在正常饮食情况下任何合适时间点进行取血检测。Objective To compare the difference between fasting blood lipids and non-fasting blood lipids in children in Tianjin,and to explore the feasibility of non-fasting blood lipids detection in children.Methods A total of 223 child patients were enrolled in Department of Pediatrics,the Second Hospital of Tianjin Medical University from January 2017 to February 2018,fasting and 1-6 h post-dining blood samples were collected from each patient.Total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C)and low-density lipoprotein cholesterol (LDL-C)were measured.Self-control methods were used.Wilcoxon signed rank test was used for statisti-cal analysis.Results Compared with fasting lipids,non-fasting TC increased with 0.02 mmol/L,TG increased with 0.01 mmol/L,HDL-C increased with 0.03 mmol/L,while LDL-C decreased with 0.01 mmol/L,but non-high-density lipoprotein cholesterol did not change.Among them,only the difference in HDL -C between the fasting and non-fasting was statistically significant (Z= -2.870,P<0.05).The difference in the change rate of all indicators was <3%.According to the dyslipidemia group comparison,the differences in hypercholesterolemia (0.72 mmol/L, Z= -2.551,P=0.011),hypertriglyceridemia (0.73 mmol/L,Z= -3. 846,P<0.001),low high-density lipopro-tein cholesterolemia (-0.04 mmol/L,Z = -8.625,P <0.001)and normal level HDL -C (0.1 mmol/L,Z =-5.040,P<0.001)between non -fasting lipids and fasting blood lipids were statistically significant.Conclusions The change of children's blood lipid profile in fasting and non-fasting conditions is little.Lipid testing in children does not require fasting.Blood tests can be performed at any appropriate time point in the normal diet.

关 键 词：非空腹血脂 血脂 心血管疾病 儿童 

分 类 号：R725[医药卫生—儿科]